The Morphology of Human Conjunctival Mucus

Adams, Alistair D.

doi:10.1001/archopht.1979.01020010382023

Cited by 63 publications

(19 citation statements)

References 21 publications

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“…The aqueous component, together with the blink mechanism, removes the mucus strands. 32 Decreased aqueous production on the dry surface of the ocular prosthesis inhibits this selfcleansing mechanism in the anophthalmic socket, leading to mucoid discharge. This is why many prosthetic eye wearers use aqueous lubricants for comfort.…”

Section: Discussionmentioning

confidence: 40%

Short-term effects of topical cyclosporine A 0.05% (Restasis) in long-standing prosthetic eye wearers: a pilot study

Han

Yoon

Jang

2014

Eye

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Purpose Long-standing prosthetic eye wearing induces ocular surface inflammation. We investigated the short-term effects of topical cyclosporine A 0.05% (Restasis) in patients with ocular discomfort resulting from long-standing prosthetic eye wearing. Methods This was a prospective, interventional case series. Patients who were unilateral prosthetic eye wearers over a period of 5 years were enrolled at a single institution from March to July 2013. The subjects were instructed to instill topical cyclosporine A 0.05% twice per day. Measurements were made pre-treatment and after 1 and 3 months of treatment. Outcome measures were the ocular symptom score, the lid margin abnormality score, the Schirmer test, and the tear meniscus amount, using Fourier-domain optical coherence tomography. Results In total, 20 consecutive patients (mean age: 60.1 years, 8 males, 12 females) were included. Ocular symptoms were improved after treatment for 1 month in all patients (ocular symptom score pre-treatment 76.83 vs 46.75 after treatment; Po0.001). There was no statistically significant difference in lid margin abnormality score or tear meniscus amount. The Schirmer test results were improved after treatment for 3 months (pre-and after treatment, 6.70 vs 11.40; Po0.001). Conclusions Topical cyclosporine A 0.05% showed a satisfactory effect in long-standing prosthetic eye wearers. Ocular symptoms were markedly relieved in all subjects after treatment for 1 month.

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Section: Discussionmentioning

confidence: 40%

Short-term effects of topical cyclosporine A 0.05% (Restasis) in long-standing prosthetic eye wearers: a pilot study

Han

Yoon

Jang

2014

Eye

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“…Also, the small patches and clumps of optically dense material (corresponding to clusters or granulae on the normal conjunctiva? 3,4 ), as well as some of the sheet-like structures apparently detached in toto from the (superior tarsal?) conjunctiva, and more complex structures resembling mucus plaques reported previously in KCS 10 adhered to abnormal surface cells.…”

Section: Discussionmentioning

confidence: 44%

“…The mechanisms behind the development of strands and sheets on the normal conjunctival surface are not fully understood. It has been suggested that the strands are the result of sheets rolling up at their edges, 3 or that the , apparently interconnected by a transparent sheet rolling up at the edges (bowed lines, arrows; cf. also (h) and (i)) show darker spots (arrowheads) suggestive of ruptured and coiled interconnecting strands; the figure appears unstained with rose bengal.…”

Section: Discussionmentioning

confidence: 44%

“…The formed material showed striking similarities to formed mucus present on normal conjunctival epithelial surface (clusters, granular sheets and strands, 3 and fine and coarser mucus strands, sheets and granules 4 ). The mechanisms behind the development of strands and sheets on the normal conjunctival surface are not fully understood.…”

Section: Discussionmentioning

confidence: 45%

“…2 Mucus showing definite morphological features has been reported on the conjunctival surface. Light microscopy, with the aid of India ink particles and filter impressions, 3 and scanning electron microscopy in conjunctival biopsies, 4 have shown that the normal conjunctival surface is covered by mucus in the form of strands, sheets, and granules. This form of mucus has been suggested to serve the elimination of exfoliated cells and extraneous particles adhering to the surface, by entrapping and removing them during blinks, and by subsequently transporting them to the fornices in which they appear as 'mucous thread'.…”

Section: Introductionmentioning

confidence: 47%

See 2 more Smart Citations

Corneal surface changes in keratoconjunctivitis sicca. Part II: the mucus component. A non-contact photomicrographic in vivo study in the human cornea

Tabery

2003

Eye

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Ingress of India Ink Into the Anterior Chamber Through Sutureless Clear Corneal Cataract Wounds

et al. 2005

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Background: Sutureless clear corneal cataract incisions may be associated with an increased risk of endophthalmitis.Objective: To assess the degree of ocular surface fluid ingress into the anterior chamber of cadaveric human globes with clear corneal wounds. Methods: Self-sealing clear corneal incisions were created in 4 eyes, and intraocular pressure was controlled with an infusion cannula. To evaluate possible flow of surface fluid through the corneal wound, india ink was applied to the corneal surface while the intraocular pressure was varied, so as to simulate the intraocular pressure fluctuations secondary to blinking or eye squeezing. The optical density from aqueous samples of globes were measured both before and after india ink application using a spectrophotometer.Results: Aqueous aspirates from the 3 globes with sutureless clear corneal wounds revealed a significant increase in spectrophotometric readings (PϽ.01), in contrast to the sutured wound, which did not show an increase in absorbance level relative to the baseline. Ink particles were both grossly and microscopically visible inside the sutureless corneal wounds.Conclusions: Fluctuations of intraocular pressure following sutureless clear corneal cataract surgery may allow entry of surface fluid into the anterior chamber during the initial postoperative period when the wound is not healed.

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The Morphology of Human Conjunctival Mucus

Cited by 63 publications

References 21 publications

Short-term effects of topical cyclosporine A 0.05% (Restasis) in long-standing prosthetic eye wearers: a pilot study

Short-term effects of topical cyclosporine A 0.05% (Restasis) in long-standing prosthetic eye wearers: a pilot study

Corneal surface changes in keratoconjunctivitis sicca. Part II: the mucus component. A non-contact photomicrographic in vivo study in the human cornea

Ingress of India Ink Into the Anterior Chamber Through Sutureless Clear Corneal Cataract Wounds

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