The Morphology of Mosaicism: Characterizing Low- And High-Level Mosaic Embryos Compared to Euploid Embryos

Abstract

150 saliva samples were obtained and correlated with number and size of follicles.Weak correlation (r¼ 0.37) was seen in salivary oestradiol to total number of follicles A more promising correlation (r¼ 0.42) was observed when total number of follicles were adjusted to above 14mm.No correlation was detected in progesterone levels to follicular growth. No relationship was observed in salivary oestradiol or progesterone to endometrial thickness.CONCLUSIONS: These preliminary results show promising findings for correlation of saliva oestradiol to follicular growth to be explored in larger studies.The limitations of saliva sample include discoloured saliva samples, which is likely secondary to poor sampling technique or failure to collect according to protocol, all of which can be mitigated with improved training and education.The ease of saliva sampling allows a reduction in intervention and thereby provides a more "patient-friendly" approach to IVF.IMPACT STATEMENT: Current status quo of serial serum monitoring should be challenged as excessive.This alternative method of monitoring of cycle response in place of serum testing, especially during mid-cycle stimulation at day 5 or 6, is worth exploring.These preliminary results call for larger studies and has potential to revolutionise development of home testing kits, especially in the era of a pandemic, thereby reducing clinic footfall and patient safety.References