The morphology of postponed senescence in <i>Drosophila melanogaster</i>

Rose, Michael R.; Dorey, Maria L.; Coyle, Anne M.; Service, Philip M.

doi:10.1139/z84-230

Cited by 54 publications

(32 citation statements)

References 18 publications

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“…All Drosophila melanogaster stocks used in these experiments were ultimately derived from a sample (called ''IV'') of the Amherst, Massachusetts, Ives population that was collected in 1975 and cultured at moderate to large population sizes ever since (Rose et al 1984;Rose et al 2004). This population has been reared at controlled densities (50-80 eggs per vial) for more than 700 generations with discrete generations cultured every 2 weeks.…”

Section: Drosophila Population Employedmentioning

confidence: 99%

Pioglitazone: an anti-diabetic compound with anti-aging properties

et al. 2007

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Insulin and Insulin-Growth-Factor-like (IGF) signaling pathways are well known longevity pathways in nematodes, insects and mammals. To our knowledge, there are no systematic pharmacological studies evaluating the anti-aging properties of medications that target this pathway in Drosophila. Although there are no published data implicating an anti-aging role for these compounds in Drosophila, we hypothesized that their promising pharmacological profile might decrease mortality. However, the decrease in mortality could be due to a number of potential artifacts and confounds such as fecundity depression, decrease in metabolic rate, or CNS depression. Therefore, the mere finding that a compound decreases mortality does not qualify it as an anti-aging compound. In this study, we evaluated the anti-aging properties of four compounds that might target the insulin signaling pathway in Drosophila. Once it was established that the compound decreased mortality, we proceeded to evaluate possible confounding factors that could have contributed to the mortality reduction. We show that only piolglitazone displayed anti-aging properties. At present, we do not have a mechanistic explanation for this pharmacological disparity.

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Section: Drosophila Population Employedmentioning

confidence: 99%

Pioglitazone: an anti-diabetic compound with anti-aging properties

et al. 2007

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“…For more details, consult ROSE (1984) or SERVICE et al (1985). These stocks exhibit increased male and female longevities, decreased early fecundity, decreased early ovary weight, increased resistance to certain stresses, decreased early metabolic rate, increased lipid content, decreased early locomotor activity, and increased later locomotor activity (ROSE 1984;ROSE et al 1984;SERVICE et al 1985;SERVICE 1987), relative to the control stocks. The control stocks, called " B s , were maintained using the same media and procedures as the 0 stocks, except that females of 14 days of age were used to start each generation.…”

Section: Stocksmentioning

confidence: 99%

“…This procedure also involves pop- The D. melanogaster populations that have been created using these methods have been analyzed in two different ways. First, these populations have been compared with control populations, of identical origin but lacking postponed aging, with regard to morphology ( ROSE et al 1984;LUCKINBILL et al 1988a) and physiology ( SERVICE et al 1985;SERVICE 1987; LUCK- INBILL et al 1988a; GRAVES, LUCKINBILL and NI- CHOLLS 1988). This research has endeavored to find mechanisms that could causally account for the postponed aging of the selected lines.…”

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confidence: 99%

Quantitative Genetics of Postponed Aging in Drosophila melanogaster. I. Analysis of Outbred Populations

Hutchinson

Rose

2004

Methuselah Flies

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Selection has been used to create replicated outbred stocks of Drosophila melanogaster with increased longevity, increased later fecundity, and increased levels of physiological performance at later ages. The present study analyzed the quantitative transmission patterns of such stocks, employing extensive replication in numbers of stocks, individuals, and assayed characters. The populations used derived from five lines with postponed aging and five control lines, all created in 1980 from the same founding base population. The following characters were studied: early 24-hr fecundity, early ovary weight, early female starvation resistance, early male starvation resistance, female longevity and male longevity. Numerous crosses were performed to test for non-Mendelian inheritance, average dominance, maternal effects, sex-linkage and between-line heterogeneity. There was only slight evidence for any of these phenomena arising reproducibly in the characters studied. These findings suggest the value of this set of stocks for studies of the physiological basis of postponed aging. GRICLIATTI 1984). This limitation on genetic analysis arises because Drosophila spp. are subject to inbreeding depression for fitness-related characters, like longevity (CLARKE and MAYNARD SMITH 1955), making the isolation of mutant strains with postponed aging very difficult.The use of selection is feasible for two reasons. First, there is abundant quantitative genetic variability for life-historical characters in outbred stocks of D. melanogaster (ROSE and CHARLESWORTH 198 la,b). Secondly, an indirect selection procedure can be used, in which natural selection is directed to act at later ages by the use of eggs laid by older females exclusively. When applied repeatedly over a number of generations, this type of selective screen leads to the evolution of postponed aging (WATTIAUX 1968a,b; ROSE and CHARLESWORTH 198 I b; ROSE 1984; LUCK- INBILL et al. 1984). This procedure also involves pop-'

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“…The obvious experimental design for the study of organisms whose aging is genetically postponed is to compare the physiological properties of such organisms with those from control populations (e.g., Rose et al, 1984;Service et al, 1985;Service, 1987;Luckinbill et al, 1988). An analogous strategy can be used with organisms that have undergone physiological postponed aging as a result of an environmental treatment, such as dietary restriction (reviewed by Masoro, 1988;Weindruch and Walford, 1988).…”

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confidence: 99%

SELECTION ON STRESS RESISTANCE INCREASES LONGEVITY IN DROSOPHILA MELANOGASTER

Rose

Park

et al. 2004

Methuselah Flies

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--Tests for the causal involvement of specific physiological mechanisms in the control of aging require evidence that these mechanisms can be used to increase longevity or reproductive lifespan. Selection for later reproduction in Drosophila has been shown to lead to increased longevity, as well as increased resistance to starvation and desiccation stresses. Selection for increased resistance to starvation and desiccation in Drosophila melanogaster is here shown to lead to increased longevity, indicating that alleles that increase stress resistance also may increase longevity. The responses of desiccation and starvation resistance to selection are partly independent of each other, indicating a multiplicity of physiological mechanisms involved in selectively postponed aging, and thus aging in general.

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The morphology of postponed senescence in Drosophila melanogaster

Cited by 54 publications

References 18 publications

Pioglitazone: an anti-diabetic compound with anti-aging properties

Pioglitazone: an anti-diabetic compound with anti-aging properties

Quantitative Genetics of Postponed Aging in Drosophila melanogaster. I. Analysis of Outbred Populations

SELECTION ON STRESS RESISTANCE INCREASES LONGEVITY IN DROSOPHILA MELANOGASTER

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