The morphology of succinic acid crystals: The role of solvent interaction

Voort, E. van der

doi:10.1016/0022-0248(91)90621-b

Cited by 20 publications

(23 citation statements)

References 14 publications

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“…The larger shape factors for succinic acid particles generated from isopropyl alcohol solution as compared with those from water are consistent with the lower solubility of SA in IP that in turn would produces smaller primary particles and hence higher agglomerate for the same size particle. It might also be possible to explain the data shown in Figure 22 by considering the fact that macroscopic succinic acid crystals grown from water have plate like shapes and those grown from isopropyl alcohol are needle shaped (Davey and Garside 2000;Van der Voort 1991). The derived DSF shown in Figure 22 are consistent with these particle shapes as well.…”

Section: Succinic Acid Lauric Acid and Their Binary Mixtures Witmentioning

confidence: 58%

From Agglomerates of Spheres to Irregularly Shaped Particles: Determination of Dynamic Shape Factors from Measurements of Mobility and Vacuum Aerodynamic Diameters

Zelenyuk

Cai

Imre³

2006

Aerosol Science and Technology

195

214

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With the advent of advanced real-time aerosol instrumentation, it has become possible to simultaneously measure individual particle mobility and vacuum aerodynamic diameters. This paper presents an experimental exploration of the effect of particle shape on the relationship between mobility and vacuum aerodynamic diameters. We make measurements on systems of three types: (1) Agglomerates of spheres, for which the density and the volume are known; (2) Ammonium sulfate, sodium chloride, succinic acid and lauric acid irregularly shaped particles of known density; and (3) Internally mixed particles, containing organics and ammonium sulfate, of unknown density and shape. For agglomerates of spheres we observe and quantify alignment effects in the Differential Mobility Analyzer (DMA), an important consequence of which is that mobility diameter of aspherical particles can be a function of DMA operating voltages. We report the first measurements of the dynamic shape factors (DSFs) in free molecular regime. We report the first experimental determination of DSF for ammonium sulfate particles, for which we find DSF to increase from 1.03 to 1.07 as particle mobility diameter increases from 160 nm to 500 nm. Three types of NaCl particles were generated and characterized: nearly spherical particles with DSF of ∼1.02; cubic with DSF that increases from 1.06 to 1.17 as particle mobility diameter increases; and compact agglomerates with DSF 1.3-1.4. Organic particles were found to be nearly spherical. The data suggest that ad

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Section: Succinic Acid Lauric Acid and Their Binary Mixtures Witmentioning

confidence: 58%

From Agglomerates of Spheres to Irregularly Shaped Particles: Determination of Dynamic Shape Factors from Measurements of Mobility and Vacuum Aerodynamic Diameters

Zelenyuk

Cai

Imre³

2006

Aerosol Science and Technology

195

214

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“…Since its inception this model has been used extensively to predict crystal shapes [41,[48][49][50][51][52] and remains routinely used today. The underlying principle, which can be proved, is that if stronger bonds are formed when a growth unit attaches to a face, then this process will require less time and lead to a faster growth rate [43,47,53]:…”

Section: Attachment Energy (Ae) Modelmentioning

confidence: 99%

A design aid for crystal growth engineering

Tilbury

Kim

et al. 2016

Progress in Materials Science

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With the highly competitive development of chemical and pharmaceutical industries, mastering crystal growth is becoming increasingly necessary. Modern industrial manufacturers place high importance on the ability to grow crystals with a specific habit using tailored operating conditions. A detailed understanding of crystal growth is, therefore, vital for researchers in crystallography and crystallization to respond and realize this objective. Various models to predict crystal shape in the literature are reviewed here. The most commonly adopted are usually non-mechanistic and limited in their predictive power and utility, especially for products of industrial interest. Mechanistic models offer far more potential for rational crystal design, but

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“…Succinic acid crystals grow by sublimation as blocks, from H 2 O as plates, and as needles from isopropanol. 62 The H-bonded chains are parallel to the ac diagonal, Figure 12 b. The 1D motif is not aligned with the unit cell, and needle growth can be controlled by solvent choice.…”

Section: Resultsmentioning

confidence: 99%

Factors Controlling Persistent Needle Crystal Growth: The Importance of Dominant One-Dimensional Secondary Bonding, Stacked Structures, and van der Waals Contact

Civati

O’Malley

Erxleben

et al. 2021

Crystal Growth & Design

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Needle crystals can cause filtering and handling problems in industrial settings, and the factors leading to a needle crystal morphology have been investigated. The crystal growth of the amide and methyl, ethyl, isopropyl, and t-butyl esters of diflunisal have been examined, and needle growth has been observed for all except the t-butyl ester. Their crystal structures show that the t-butyl ester is the only structure that does not contain molecular stacking. A second polymorph of a persistent needle forming phenylsulfonamide with a block like habit has been isolated. The structure analysis has been extended to known needle forming systems from the literature. The intermolecular interactions in needle forming structures have been analyzed using the PIXEL program, and the properties driving needle crystal growth were found to include a 1D motif with interaction energy greater than −30 kJ/mol, at least 50% vdW contact between the motif neighbors, and a filled unit cell which is a monolayer. Crystal structures are classified into persistent and controllable needle formers. Needle growth in the latter class can be controlled by choice of solvent. The factors shown here to be drivers of needle growth will help in the design of processes for the production of less problematic crystal products.

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The morphology of succinic acid crystals: The role of solvent interaction

Cited by 20 publications

References 14 publications

From Agglomerates of Spheres to Irregularly Shaped Particles: Determination of Dynamic Shape Factors from Measurements of Mobility and Vacuum Aerodynamic Diameters

From Agglomerates of Spheres to Irregularly Shaped Particles: Determination of Dynamic Shape Factors from Measurements of Mobility and Vacuum Aerodynamic Diameters

A design aid for crystal growth engineering

Factors Controlling Persistent Needle Crystal Growth: The Importance of Dominant One-Dimensional Secondary Bonding, Stacked Structures, and van der Waals Contact

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