The most common chromosome change in 86 chronic B cell or T cell tumors: A 14q32 translocation

Nowell̀, Peter C.; Vonderheid, Eric C.; Besa, Emmanuel C.; Hoxie, James A.; Moreau, Lisa A.; Finan, Janet

doi:10.1016/0165-4608(86)90050-6

Cited by 70 publications

(45 citation statements)

References 35 publications

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“…There has been a speculation about the pathogenetic role of this gene in B-CLL [16,17]. Loss of both alleles by mutation or deletion appears to be involved in the initiation or progression of the variety of solid tumors [13]. But the biallelic deletions of RB1 are rarely found in B-CLL and were not observed in our study.…”

Section: Discussioncontrasting

confidence: 50%

“…Because del(11q) is clinically significant, it is necessary to detect it with FISH and CGH methods in patients with CLL. The clinical importance of deletion 17p, to which the p53 tumor suppressor gene locates, has been identified in most studies [2,4,8,13]. The survival of patients with p53 deletion was significantly shorter than the survival of patients without deletion.…”

Section: Discussionmentioning

confidence: 99%

“…These may be detected alone or with other chromosomal abnormalities.Trisomy 12 and deletion 13q coexist in a minority of CLL patients [6]. Other chromosome abnormalities that were reported with varying frequency included deletions of 6q [8][9][10], 11q [5,8,11], 17p [2,3,12] and changes involving 14q32 [8,13]. Deletion of 17p has a strong impact on the clinical outcome of the disease.…”

Section: Introductionmentioning

confidence: 99%

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Contribution of Comparative Genomic Hybridization and Fluorescence in situ Hybridization to the Detection of Chromosomal Abnormalities in B-Cell Chronic Lymphocytic Leukemia

Jarošová

Jedlickova²,

Holzerová³

et al. 2001

Oncol Res Treat

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Background: B-chronic lymphocytic leukemia (B-CLL), the most common type of leukemia in Western Europe and the United States, is characterized by clonal chromosomal abnormalities detected in almost half of the studied patients. The precise determination of chromosomal changes helps to indicate the prognosis and to understand the pathogenesis of CLL. Methods and Patients: We applied conventional cytogenetics (CC), FISH and comparative genomic hybridization (CGH) to the investigation of clonal abnormalities in 88 B-CLL patients at the time of diagnosis. Results: By using CC of bone marrow cells without any stimulation, non-random chromosomal changes were found in 17 (19%) of 88 patients.The employment of FISH and CGH revealed chromosomal changes in additional 33 patients, thus increasing the detection rate of chromosomal abnormalities to 57%. The most common abnormalities detected in our patients included deletions of 13q in 16 cases (18%), followed by trisomy of chromosome 12 in 12 patients (13%), deletions of 11q in 10 patients (11%) and deletions of 17p in 10 patients (11%). A statistically significant correlation between higher disease activity and the presence of deletions 11q and 17p was observed. Conclusion: The addition of FISH and CGH to CC in 88 B-CLL patients improved the detection of clonal chromosomal changes from 19 to 57%. The most frequent chromosomal change was deletion of 13q14 (18%). Deletions of 11q23 and 17p13 were found in patients with higher clinical disease activity. Our results underline the importance of employing FISH and CGH techniques in CLL patients. CC without any stimulation has a low detection rate and is not suggested for detection of chromosomal changes in CLL.

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Contribution of Comparative Genomic Hybridization and Fluorescence in situ Hybridization to the Detection of Chromosomal Abnormalities in B-Cell Chronic Lymphocytic Leukemia

Jarošová

Jedlickova²,

Holzerová³

et al. 2001

Oncol Res Treat

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“…This combination has been previously found to stimulate optimal proliferative responses in SzS T cells (21). Cultures were maintained in 24-well flat-bottom plates (Becton Dickinson) for 24 hr at 37°C and 5% CO2 in AIM-V with 2 mM L-glutamine.…”

Section: Methodsmentioning

confidence: 99%

Reduced surface expression of transforming growth factor beta receptor type II in mitogen-activated T cells from Sézary patients.

Capocasale

Lamb

Vonderheid

et al. 1995

Proc. Natl. Acad. Sci. U.S.A.

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“…In B-cell chronic lymphocytic leukemia (CLL), a gain of chromosome 12 and translocations involving 14q32 are the most frequent chromosomal aberrations (5,6). The presence of karyotypic abnormalities is associated with a poor prognosis.…”

mentioning

confidence: 99%

Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia.

McKeithan

Rowley

Shows

et al. 1987

Proc. Natl. Acad. Sci. U.S.A.

102

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The most common chromosome change in 86 chronic B cell or T cell tumors: A 14q32 translocation

Cited by 70 publications

References 35 publications

Contribution of Comparative Genomic Hybridization and Fluorescence in situ Hybridization to the Detection of Chromosomal Abnormalities in B-Cell Chronic Lymphocytic Leukemia

Contribution of Comparative Genomic Hybridization and Fluorescence in situ Hybridization to the Detection of Chromosomal Abnormalities in B-Cell Chronic Lymphocytic Leukemia

Reduced surface expression of transforming growth factor beta receptor type II in mitogen-activated T cells from Sézary patients.

Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia.

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