The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial

Mozurkewich, Ellen; Clinton, Chelsea; Chilimigras, Julie L.; Hamilton, Susan; Allbaugh, Lucy J.; Berman, Deborah R.; Romero, Vivian; Treadwell, Marjorie C.; Keeton, Kristie; Vahratian, Anjel; Schrader, Ronald M.; Ren, Jianwei; Djurić, Zora

doi:10.1016/j.ajog.2013.01.038

Cited by 86 publications

(118 citation statements)

References 26 publications

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“…Mean depression score decreased significantly in the omega-3 group, but the decrement was not significant in the placebo group. Depression scores were significantly different between groups after treatment (P < 0.001) (31). The results of this study in terms of postpartum depression are consistent with our study in terms of within-group analysis, but it is inconsistent by considering between-group analysis.…”

Section: Discussionsupporting

confidence: 82%

Fish-Oil Supplementation and Maternal Mental Health: A Triple-Blind, Randomized Controlled Trial

Farshbaf‐Khalili¹,

Mohammadalizadeh²,

Farshbaf-Khalili³

et al. 2016

Iran Red Crescent Med J

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Objectives: The aim of this study was to evaluate the effect of fish oil supplementation on antenatal and postpartum depression score. Methods:This was a randomized, triple-blind, placebo-controlled trial. We enrolled 150 eligible pregnant women with Edinburgh postnatal depression scale (EPDS) score of less than 20, aged 18 to 35 from Feburary 2014 to April 2015 in Tabriz, Iran. Participants were randomly assigned to receive either 1000 mg of fish oil supplements or placebo from 16 -20 weeks of gestation to one month after giving birth. Participants completed the EPDS at baseline, 26 -30 weeks, 35 -37 weeks, and 30 -45 days after birth. Primary outcome measures were the mean depression score at 26 -30 weeks, 35-37 weeks, and postpartum period. The statistical analysis was intent-to-treat. Results:A total of 150 females were included, and no one was lost to follow up. There were significant differences between the two groups in the mean score of depression only at 35 -37 (adjusted mean difference = -1.4; [95% CI -2.6 to -0.25]). The mean score of depression during pregnancy and postpartum period significantly decreased within the fish oil group (P < 0.05). There were no significant differences between the two groups in terms of the baseline docosahexaenoic acid (DHA) and eicosapentaneoic acid (EPA) serum levels. Conclusions:Fish oil supplements significantly decreased the mean score of EPDS at weeks 35 to 37. It seems that females may benefit from daily fish oil supplements during pregnancy especially in countries with low intake of fish yet further studies are needed to confirm these results.

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Section: Discussionsupporting

confidence: 82%

Fish-Oil Supplementation and Maternal Mental Health: A Triple-Blind, Randomized Controlled Trial

Farshbaf‐Khalili¹,

Mohammadalizadeh²,

Farshbaf-Khalili³

et al. 2016

Iran Red Crescent Med J

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“…61,121,148,[164][165][166][167][168][169][170][171][172][173][174][175][176][177][178][179][193][194][195][196]205,206,[214][215][216]224,229 Study location…”

Section: Level Of Preventive Interventionunclassified

A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression

Morrell

Sutcliffe

Booth

et al. 2016

Health Technol Assess

101

105

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A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression C Jane Morrell, 1 * Paul Sutcliffe, 2 Andrew Booth, 3 John Stevens, 3 This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: http://www.nets.nihr.ac.uk/programmes/hta This reportThe research reported in this issue of the journal was funded by the HTA programme as project number 11/95/03. The contractual start date was in November 2012. The draft report began editorial review in August 2014 and was accepted for publication in June 2015. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HTA programme or the Department ...

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“…Of the former, six were randomized controlled trials (Doornbos et al, 2009;Freeman et al, 2008;Llorent et al, 2003;Makrides et al, 2010;Mozurkewich et al, 2013;Rees, Austin, & Parker, 2008) and two pilot trials (Freeman et al, 2006;Marangell et al, 2004). The nine observational studies included: one ecological study (Hibbeln, 2002), a cross-sectional study (De Vriese, Christophe, & Maes, 2003), a case-control study (Browne, Scott, & Silvers, 2006), and six cohort studies (da Rocha & Kac, 2012;Markhus et al, 2013;Miyake et al, 2006;Otto, De Groot, & Hornstra, 2003;Parker et al, 2014;Strøm, Mortensen, Halldorsson, Thorsdottir, & Olsen, 2009).…”

Section: Overall Results In Context With Expectations Arising From Thmentioning

confidence: 99%

“…Indeed, none of the studies reviewed evaluated the brain or synaptic DHA levels , while few assessed DHA levels in the plasma (Browne et al, 2006;De Vriese et al, 2003;Doornbos et al, 2009;Makrides et al, 2010;Markhus et al, 2013;Llorent et al, 2003;Mozurkewich et al, 2013;Parker et al, 2014;Rees et al, 2008).…”

Section: Discussion (Narrative Synthesis: Element 3)mentioning

confidence: 99%

Role of Omega-3 Unsaturated Fatty Acids in the Postpartum Depression: Systematic Review and Narrative Synthesis

Mougharbel¹,

Deonandan²

2016

GJHS

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Background: Postpartum depression (PPD) is a complex mental health disorder that affects women during their childbearing years. It is a serious medical condition that occurs in approximately 15% of women after birth and has an adverse effect on both the mother and the infant. Hypotheses exist relating dietary deficiencies in a pregnant or postnatal woman's diet may cause postnatal depression. It is unclear whether Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are effective for treating or preventing PPD. Objectives:To assess the best available evidence to date regarding the effect of n-3 PUFAs on the etiology, prevention and treatment of postnatal depression. Methods:A systematic review and narrative synthesis was conducted in order to address the gaps in knowledge. For the systematic review, a broad search of electronic databases of published quantitative literature was conducted. The narrative synthesis consists of four elements: 1) developing a theory; 2) developing a preliminary synthesis; 3) exploring relationships in the data; 4) assessing the robustness of the synthesis. Published experimental and observational studies were accepted involving women who were pregnant or who had given birth in the previous six weeks. N-3 PUFAs was the intervention of interest and PPD was the outcome.Results: Out of 181 potential articles, a total of 17 studies met the inclusion criteria. The overwhelming majority of the studies found that n-3 PUFAs had no inverse association with PPD evaluations. Significant heterogeneity was observed among included studies. Conclusions:Overall, This systematic review and narrative synthesis failed to find a significant positive association between n-3 PUFAs intake and PPD.

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The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial

Cited by 86 publications

References 26 publications

Fish-Oil Supplementation and Maternal Mental Health: A Triple-Blind, Randomized Controlled Trial

Fish-Oil Supplementation and Maternal Mental Health: A Triple-Blind, Randomized Controlled Trial

A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression

Role of Omega-3 Unsaturated Fatty Acids in the Postpartum Depression: Systematic Review and Narrative Synthesis

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