The mouse as a model to study adhesion formation following endoscopic surgery: a preliminary report

Yeşildağlar, Narter; Ordonez, J.L.; Laermans, I; Koninckx, Philippe

doi:10.1093/humrep/14.1.55

Cited by 32 publications

(32 citation statements)

References 17 publications

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“…In fact, Ott 114 has shown electron microscopic damage from tissue drying during laparoscopy, especially with the use of high velocity flow and dry cold gas. Also, insufflations alone have been shown to cause induction of adhesion development in mice by Yesildaglar and collaborators, 115 in both a time and flow dependent manner. We have shown that scavenging O 2 -with SOD, even in the presence of hypoxia, prevented the development of the adhesion phenotype in vitro.…”

Section: Possible Role Of Enzymes Polypeptides and Antioxidants In mentioning

confidence: 98%

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress

et al. 2014

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Over the past several years, there has been increasing recognition that pathogenesis of adhesion development includes significant contributions of hypoxia induced at the site of surgery, the resulting oxidative stress, and the subsequent free radical production. Mitochondrial dysfunction generated by surgically induced tissue hypoxia and inflammation can lead to the production of reactive oxygen and nitrogen species as well as antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase which when optimal have the potential to abrogate mitochondrial dysfunction and oxidative stress, preventing the cascade of events leading to the development of adhesions in injured peritoneum. There is a significant cross talk between the several processes leading to whether or not adhesions would eventually develop. Several of these processes present avenues for the development of measures that can help in abrogating adhesion formation or reformation after intraabdominal surgery.

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Section: Possible Role Of Enzymes Polypeptides and Antioxidants In mentioning

confidence: 98%

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress

et al. 2014

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“…Notes: EC -electrocautery, SC-scratching, PP-parietal peritoneum, VP-visceral peritoneum (uterine horns), vs-versus. [12,13] and mice [14,15] were done by the coagulation of sidewall peritoneum and ipsilateral uterine horns via a laparoscopic approach, B-modifications in rats were performed in one site by electrocautery and in the opposite site by scratching through open laparoscopy [4].…”

Section: Body Textmentioning

confidence: 99%

“…This model has been modified to evaluate an impact of CO 2 -pneumoperitoneum ( Figure 2) by laparoscopic approach in rabbits [12,13] and in mice [14,15] at KULeuven and through open laparoscopy in rats [4] by our team at Moscow State University.…”

Section: Body Textmentioning

confidence: 99%

“…By application of one surgical damaging factor-electrocautery it was possible to test only an impact of CO 2 -pneumoperitoneum [12][13][14][15]. Our model with two surgical factors such as electrocautery and scratching allowed us in addition to CO 2 -pneumoperitoneum impact to test an impact of surgical trauma type and peritoneal lesion sites (Figure 3) with fraiming subsequent working hypotheses.…”

Section: Body Textmentioning

confidence: 99%

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A Modified Sidewall Adhesion Model: Hypothesis-Building and Testing Tool for a Surgical Experimental Research

Mynbaev¹,

Eliseeva²

2014

Clinics in Mother and Child Health

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This editorial opinion article is based on our own experience and literature review. The NESA adhesion formation study team members recommend an unique model as a hypothesis building and testing tool in a surgical experimental research. Body textPostsurgical adhesions are believed to be the result of surgical tissue trauma in presence of multi factorial etiology of excessive healing, which may interfere with the physiological mechanisms at any stage [1]. The key points of postsurgical adhesions includes firstly the fixation of the intra-peritoneal structures to the parietal and/or visceral peritoneum, keeping them attached longer than in physiological wound healing [2] and secondly the initiation of excessive healing, caused by inflammation [3], which in turn may be triggered by surgical factors [4].Postsurgical adhesions have evoked hard-to-cure and high-costly problems for the healthcare systems overall with such frequent complications such as small bowel obstructions with negative effects on patients' health, and increased workloads in clinical practice [5].High-costs were associated with postsurgical adhesion complications as demonstrated in an analysis of annual inpatient care and expenditures based on a national hospital discharge data which were used to identify all abdominal adhesion related procedures performed in the United States in 1994 [6]: validated data with a ten-year followup of 12,584 patients undergoing lower abdominal surgery from the Scottish National Health Service Medical Record Linkage Database in UK [7] and in a study aimed to examine the natural course of patients following surgery for small bowel obstruction with a 14 year-follow-up in Sweden [8]. Under the evidence-based assumption that the risk of adhesions in colorectal surgery called for the necessity of opportunities and strategies for improvement the team of distinguished surgeons 'called for action' in their paper [9] to colorectal surgeons "to make prevention of adhesions more of a priority and importantly to inform patients of the risks associated with adhesion-related complications during the consent process".From this view long lasting attempts of researchers and surgeons to find an optimal adhesion preventing adjuvant have legitimated their expectations and the expenses were well worth it. Unfortunately until now most of suggested adhesion preventive adjuvant have shown their efficiency only in experimental models and failed in clinical trials.Previously we demonstrated key steps of surgical research, namely the selection of the research questions, hypothesis building to set goals as well as the elaboration of a study design and interpretation of results based on our experimental studies and a systematic review of literature [10]. In our experimental researches we aimed to study an impact of surgical trauma and CO 2 -insufflation on adhesion formation [3,10] to demonstrate the developing of research questions, the building of a hypothesis, and the setting of goals and the elaboration of a study design as well as the...

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“…Nevertheless, pneumoperitoneum-dependent alterations of the intra-abdominal microenvironment potentially also have a negative impact on adhesion formation. Animal studies have shown an increased formation of adhesions depending on the duration [28][29][30] or pressure [5] of the pneumoperitoneum. Adhesions might originate from a peritoneal trauma caused by insufflation induced desiccation [31][32][33].…”

Section: Adhesionsmentioning

confidence: 99%

Impact of pressure and gas type on adhesion formation and biomaterial integration in laparoscopy

et al. 2011

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The mouse as a model to study adhesion formation following endoscopic surgery: a preliminary report

Cited by 32 publications

References 17 publications

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress

A Modified Sidewall Adhesion Model: Hypothesis-Building and Testing Tool for a Surgical Experimental Research

Impact of pressure and gas type on adhesion formation and biomaterial integration in laparoscopy

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