The mouse resource at National Resource Center for Mutant Mice

Ju, Cunxiang; Liang, J. B.; Zhang, Mingkun; Zhao, Jinlong; Li, Ling’en; Chen, Shuai; Zhao, Jing; Gao, Xiang

doi:10.1007/s00335-021-09940-x

Cited by 4 publications

(1 citation statement)

References 88 publications

(63 reference statements)

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“…Whatever the cause of mouth grasping, we favor the view that it is a fallback strategy used by the mouse to cope with task difficulty. Thus, string-pulling and its variations is an interesting test to consider in target populations of the more than 18,500 strains of laboratory mouse (Ju et al, 2022) many of which may show variations in motor system efficiencies (Whishaw et al, 2001).…”

Section: Mouth Usementioning

confidence: 99%

Information-theory analysis of mouse string-pulling agrees with Fitts’s Law: Increasing task difficulty engages multiple sensorimotor modalities in a dual oscillator behavior

Sandhu,

Agha,

Inayat

et al. 2023

Preprint

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Mouse string pulling, in which a mouse reels in a string with hand-over-hand movements, can provide insights into skilled motor behavior, neurological status, and cognitive function. The task involves two oscillatory movements connected by the string. The snout tracks the pendulum movement of the string produced by hand-over-hand pulls and so guides the hands to grasp the string. The present study examines the allocation of time required to pull strings of varying diameter. Movement is also described with end-point measures, string-pulling topography with 2D markerless pose estimates based on transfer learning with deep neural networks, and Mat-lab image-segmentation and heuristic algorithms for object tracking. With reduced string diameter, mice took longer to pull 60cm long strings. They also made more pulling cycles, misses, and mouth engagements, and displayed changes in the amplitude and frequency of pull cycles. The time measures agree with Fitts's law in showing that increased task difficulty slows behavior and engages multiple compensatory sensorimotor modalities. The analysis reveals that time is a valuable resource in skilled motor behavior and information-theory can serve as a measure of its effective use.

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Section: Mouth Usementioning

confidence: 99%

Information-theory analysis of mouse string-pulling agrees with Fitts’s Law: Increasing task difficulty engages multiple sensorimotor modalities in a dual oscillator behavior

Sandhu,

Agha,

Inayat

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Information-theory analysis of mouse string-pulling agrees with Fitts’s Law: Increasing task difficulty engages multiple sensorimotor modalities in a dual oscillator behavior

Sandhu,

Mirza Agha,

Inayat

et al. 2024

Behavioural Brain Research

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A prioritization tool for cilia-associated genes and their in vivo resources unveils new avenues for ciliopathy research

Van Sciver,

Caspary

2024

Disease Models &Amp; Mechanisms

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Defects in ciliary signaling or mutations in proteins that localize to primary cilia lead to a class of human diseases known as ciliopathies. About 10% of mammalian genes encode cilia-associated proteins and a major gap in the cilia research field is prioritizing which genes to study and finding the in vivo vertebrate mutant alleles and reagents available for their study. Here we present a unified resource listing the cilia-associated human genes cross-referenced to available mouse and zebrafish mutant alleles, their associated phenotypes as well as expression data in kidney and functional data for vertebrate Hedgehog signaling. This resource empowers researchers to easily sort and filter genes based on their own expertise and priorities, cross-reference with newly-generated -omics datasets, and quickly find in vivo resources and phenotypes associated with a gene of interest.

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The mouse resource at National Resource Center for Mutant Mice

Cited by 4 publications

References 88 publications

Information-theory analysis of mouse string-pulling agrees with Fitts’s Law: Increasing task difficulty engages multiple sensorimotor modalities in a dual oscillator behavior

Information-theory analysis of mouse string-pulling agrees with Fitts’s Law: Increasing task difficulty engages multiple sensorimotor modalities in a dual oscillator behavior

Information-theory analysis of mouse string-pulling agrees with Fitts’s Law: Increasing task difficulty engages multiple sensorimotor modalities in a dual oscillator behavior

A prioritization tool for cilia-associated genes and their in vivo resources unveils new avenues for ciliopathy research

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