1981
DOI: 10.1016/0165-1110(81)90010-5
|View full text |Cite
|
Sign up to set email alerts
|

The mouse specific-locus test with agents other than radiations

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
9
0

Year Published

1988
1988
2016
2016

Publication Types

Select...
6
4

Relationship

0
10

Authors

Journals

citations
Cited by 132 publications
(9 citation statements)
references
References 24 publications
0
9
0
Order By: Relevance
“…Four chemicals yielded positive results in both stem cells and later stages, four were negative in both stages (by Genetox criteria, ref. 22), and five were positive in post-stem-cell stages but negative in stem cells. Chlorambucil falls into this last group (the others being ethyl methanesulfonate, diethyl sulfate, cyclophosphamide, and acrylamide monomer).…”
Section: Discussionmentioning
confidence: 99%
“…Four chemicals yielded positive results in both stem cells and later stages, four were negative in both stages (by Genetox criteria, ref. 22), and five were positive in post-stem-cell stages but negative in stem cells. Chlorambucil falls into this last group (the others being ethyl methanesulfonate, diethyl sulfate, cyclophosphamide, and acrylamide monomer).…”
Section: Discussionmentioning
confidence: 99%
“…The BaP mutation spectrum is less well characterized in germ cells. While BaP can induce mutations during various phases of spermatogenesis, including stem cells, dividing spermatogonia appear to be the most sensitive121319202526. The characteristic G:C to T:A transversion also appears to be the primary BaP-induced mutation detected in sperm13.…”
mentioning
confidence: 99%
“…Results for the specific locus test were negative or inconclusive for pre- and post-spermatogonial germ cells after i.p. injection ( Russell et al , 1981 ). Recent studies using TGR models have reported increases in the mutant frequencies (MF) of lacZ ( Verhofstad et al , 2011 ) and cII reporter genes ( Olsen et al , 2010 ) in mouse sperm collected 42 and 119 days after oral exposure to BaP, respectively.…”
mentioning
confidence: 99%