The mRNA expression profile of cytokines connected to the regulation of melanocyte functioning in vitiligo skin biopsy samples and peripheral blood mononuclear cells

Reimann, Ene; Kingo, Külli; Karelson, Maire; Reemann, Paula; Loite, Ulvi; Sulakatko, Helen; Keermann, Maris; Raud, Kristi; Abram, Kristi; Vasar, Eero; Silm, Helgi; Kõks, Sulev

doi:10.1016/j.humimm.2012.01.011

Cited by 26 publications

(25 citation statements)

References 34 publications

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“…In our previous work, IL22RA2 mRNA was upregulated in uninvolved skin of vitiligo patients compared to involved and control skin [12]. Further analysis indicated a downregulation of IL22RA2 mRNA in involved skin of active vitiligio patients [12]. We have also demonstrated an upregulated state of proinflammatory IL-22 in vitiligo patients [15].…”

Section: Discussionsupporting

confidence: 51%

“…IL-22BP is a soluble monomeric protein that binds IL-22, functioning as its antagonist. In our previous work, IL22RA2 mRNA was upregulated in uninvolved skin of vitiligo patients compared to involved and control skin [12]. Further analysis indicated a downregulation of IL22RA2 mRNA in involved skin of active vitiligio patients [12].…”

Section: Discussionmentioning

confidence: 75%

“…The expression of MDM1 and all three cytokine genes of this cluster has been measured in vitiligo patients in the course of our previous studies. IFNG mRNA expression was increased in vitiligo involved skin and in PBMCs of the patients [12]. IL26 levels in skin did not differ between patients and controls [12].…”

Section: Discussionmentioning

confidence: 77%

“…The corresponding genes IFNG, L26, and IL22 of these cytokines form a cluster at 12q15 chromosomal region. The functions of adjacently placed MDM1 gene are yet to be established, but the mRNA levels were increased in vitiligo skin and peripheral blood mononuclear cells (PBMCs) in our recent report [12]. Another group of cytokines are IL-28B, IL-28A and IL-29 (alternatively labeled IFN-λ3, IFN-λ2 and IFN-λ1, respectively) encoded by gene cluster of IL28B, IL28A and IL29 in the 19q13.2 chromosomal region.…”

Section: Introductionmentioning

confidence: 71%

“…Notably, IL22 expression was elevated in vitiligo patients along with one of its receptor subunits IL10RB [15]. A following study demonstrated changes in mRNA expression pattern of IL20RB, IL22RA2, IL28A, IL28B, IL28RA,MDM1, IFNA1, IFNB1, IFNG, and ICAM1 in skin and/or PBMCs of vitiligo patients [12]. Additionally, genetic associations were found with SNPs of IL19, IL20, and IL20RB genes [16].…”

Section: Introductionmentioning

confidence: 77%

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Association analysis of class II cytokine and receptor genes in vitiligo patients

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 77%

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Association analysis of class II cytokine and receptor genes in vitiligo patients

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The role of the IL-22/IL-22R1 axis in cancer

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NKG2D Defines a Subset of Skin Effector Memory CD8 T Cells with Proinflammatory Functions in Vitiligo

Jacquemin

Martins

Lucchese

et al. 2020

Journal of Investigative Dermatology

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Vitiligo is an autoimmune disease that results from the loss of melanocytes, associated with skin infiltration of CD8 þ effector memory T cells with a Tc1 skewed immune response. NKG2D is an activating receptor found on immune cells, in particular natural killer and activated CD8 þ T cells, that are able to produce a high amount of IFN-g. Here we found that NKG2D expression was increased in vitiligo skin CD8 þ effector memory T cells and was promoted by IL-15. Phenotypic and functional analyses showed that NKG2D þ CD8 þ skin effector memory T cells displayed an activated phenotype and produced elevated levels of both IFN-g and tumor necrosis factor-a. Additional experiments revealed that vitiligo skin dendritic cells expressed the NKG2D ligands MICA-MICB, and in vitro experiments showed that these ligands could be induced on dendritic cells by IFN-a. Cultures of IFN-aestimulated dendritic cells with skin NKG2D þ CD8 þ T cells potentiated the production of type 1 cytokines, which was next inhibited by blocking the NKG2D/MICA-MICB interaction. These data show that NKG2D is a potential marker of pathogenic skin CD8 þ effector memory T cells during vitiligo. Therefore, targeting NKG2D could be an attractive strategy in vitiligo, a disease for which there is a strong need of innovative treatments.

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The mRNA expression profile of cytokines connected to the regulation of melanocyte functioning in vitiligo skin biopsy samples and peripheral blood mononuclear cells

Cited by 26 publications

References 34 publications

Association analysis of class II cytokine and receptor genes in vitiligo patients

Association analysis of class II cytokine and receptor genes in vitiligo patients

The role of the IL-22/IL-22R1 axis in cancer

NKG2D Defines a Subset of Skin Effector Memory CD8 T Cells with Proinflammatory Functions in Vitiligo

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