The MSL complex: X chromosome and beyond

Laverty, Corey; Lucci, Jacopo; Akhtar, Asifa

doi:10.1016/j.gde.2010.01.007

Cited by 27 publications

(21 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is becoming increasingly clear that the replication program responds to many of the same epigenetic cues that regulate the transcription program. For example, X chromosome dosage compensation in the fly results not only in the H4K16ac-dependent transcriptional up-regulation of X-specific genes in male cells (Laverty et al 2010), but also a sex chromosome-specific change in replication timing (Schwaiger et al 2009). Similarly, we find that ORC, early origins, and early replicating regions of the genome are highly enriched for activating chromatin marks (H3K4me, H3K18ac, H3K27ac, etc.).…”

Section: Discussionmentioning

confidence: 99%

Chromatin signatures of the Drosophila replication program

Eaton

Prinz²,

MacAlpine³

et al. 2010

Genome Res.

165

203

View full text Add to dashboard Cite

DNA replication initiates from thousands of start sites throughout the Drosophila genome and must be coordinated with other ongoing nuclear processes such as transcription to ensure genetic and epigenetic inheritance. Considerable progress has been made toward understanding how chromatin modifications regulate the transcription program; in contrast, we know relatively little about the role of the chromatin landscape in defining how start sites of DNA replication are selected and regulated. Here, we describe the Drosophila replication program in the context of the chromatin and transcription landscape for multiple cell lines using data generated by the modENCODE consortium. We find that while the cell lines exhibit similar replication programs, there are numerous cell line-specific differences that correlate with changes in the chromatin architecture. We identify chromatin features that are associated with replication timing, early origin usage, and ORC binding. Primary sequence, activating chromatin marks, and DNA-binding proteins (including chromatin remodelers) contribute in an additive manner to specify ORC-binding sites. We also generate accurate and predictive models from the chromatin data to describe origin usage and strength between cell lines. Multiple activating chromatin modifications contribute to the function and relative strength of replication origins, suggesting that the chromatin environment does not regulate origins of replication as a simple binary switch, but rather acts as a tunable rheostat to regulate replication initiation events.

show abstract

Section: Discussionmentioning

confidence: 99%

Chromatin signatures of the Drosophila replication program

Eaton

Prinz²,

MacAlpine³

et al. 2010

Genome Res.

165

203

View full text Add to dashboard Cite

show abstract

“…In Drosophila , the MSL complex implements H4K16 acetylation on the male X chromosome to achieve dosage compensation. In both Drosophila and mammals, a related H4K16 acetylation complex modifies histones in both males and females on all chromosomes for proper gene expression genome-wide (115). In C. elegans , a condensin complex (called the DCC for d osage c ompensation c omplex) shares subunits with the chromosome compaction machinery necessary for the faithful segregation of the mitotic and meiotic chromosomes (113, 116–119).…”

Section: - Identification Of the Metazoans Set1/trx/mll In Compass-mentioning

confidence: 99%

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

Shilatifard

2012

Annu. Rev. Biochem.

959

1,079

View full text Add to dashboard Cite

The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4) methylase identified over ten years ago. Since then, it has been demonstrated that Set1/COMPASS and its enzymatic product, H3K4 methylation, is highly conserved across the evolutionary tree. Although there is only one COMPASS in yeast, human cells bear at least six COMPASS family members each capable of methylating H3K4 with non-redundant functions. In yeast, the monoubiquitination of histone H2B by Rad6/Bre1 is required for proper H3K4 and H3K79 trimethylations. This histone crosstalk and its machinery are also highly conserved from yeast to human. In this review, the process of histone H2B monoubiquitination-dependent and independent histone H3K4 methylation as a mark of active transcription, enhancer signatures, and developmentally poised genes will be discussed. The misregulation of histone H2B monoubiquitination and H3K4 methylation results in the pathogenesis of human diseases including cancer. Recent findings in this regard will also be examined.

show abstract

“…This doubling of expression of X-linked genes in males also equalizes average expression with the autosomes (AA) (i.e. X ≈ XX ≈ AA, reviewed in Gelbart and Kuroda 2009; Laverty et al. 2010; Conrad and Akhtar 2012).…”

Section: Introductionmentioning

confidence: 99%

Conserved Patterns of Sex Chromosome Dosage Compensation in the Lepidoptera (WZ/ZZ): Insights from a Moth Neo-Z Chromosome

Walters

Knipple

2017

Genome Biology and Evolution

View full text Add to dashboard Cite

Where previously described, patterns of sex chromosome dosage compensation in the Lepidoptera (moths and butterflies) have several unusual characteristics. Other female-heterogametic (ZW/ZZ) species exhibit female Z-linked expression that is reduced compared with autosomal expression and male Z expression. In the Lepidoptera, however, Z expression typically appears balanced between sexes but overall reduced relative to autosomal expression, that is Z ≈ ZZ < AA. This pattern is not easily reconciled with theoretical expectations for the evolution of sex chromosome dosage compensation. Moreover, conflicting results linger due to discrepancies in data analyses and tissues sampled among lepidopterans. To address these issues, we performed RNA-seq to analyze sex chromosome dosage compensation in the codling moth, Cydia pomonella, which is a species from the earliest diverging lepidopteran lineage yet examined for dosage compensation and has a neo-Z chromosome resulting from an ancient Z:autosome fusion. While supported by intraspecific analyses, the Z ≈ ZZ < AA pattern was further evidenced by comparative study using autosomal orthologs of C. pomonella neo-Z genes in outgroup species. In contrast, dosage compensation appears to be absent in reproductive tissues. We thus argue that inclusion of reproductive tissues may explain the incongruence from a prior study on another moth species and that patterns of dosage compensation are likely conserved in the Lepidoptera. Notably, this pattern appears convergent with patterns in eutherian mammals (X ≈ XX < AA). Overall, our results contribute to the notion that the Lepidoptera present challenges both to classical theories regarding the evolution of sex chromosome dosage compensation and the emerging view of the association of dosage compensation with sexual heterogamety.

show abstract

The MSL complex: X chromosome and beyond

Cited by 27 publications

References 63 publications

Chromatin signatures of the Drosophila replication program

Chromatin signatures of the Drosophila replication program

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

Conserved Patterns of Sex Chromosome Dosage Compensation in the Lepidoptera (WZ/ZZ): Insights from a Moth Neo-Z Chromosome

Contact Info

Product

Resources

About