The mTOR pathway in the antiphospholipid syndrome

Ji, Lanlan; Zhang, Zhuoli; Perl, Andras

doi:10.1515/mr-2023-0033

Cited by 2 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It participates in multiple biological processes, including gene transcription, protein translation, and ribosome synthesis, playing a crucial role in cell growth, apoptosis, autophagy, and metabolism ( 118 ). In APS, mTOR is primarily involved in the PI3K/Akt/mTOR signaling axis, which is crucial for regulating autophagy ( 119 ). However, the relationship between mTOR and autophagy in ECs under aPL stimulation remains ambiguous and sometimes contradictory.…”

Section: Signaling Pathways In Endothelial Cellsmentioning

confidence: 99%

Interaction of antiphospholipid antibodies with endothelial cells in antiphospholipid syndrome

Feng,

Qiao,

Tan

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Antiphospholipid syndrome (APS) is an autoimmune disease with arteriovenous thrombosis and recurrent miscarriages as the main clinical manifestations. Due to the complexity of its mechanisms and the diversity of its manifestations, its diagnosis and treatment remain challenging issues. Antiphospholipid antibodies (aPL) not only serve as crucial “biomarkers” in diagnosing APS but also act as the “culprits” of the disease. Endothelial cells (ECs), as one of the core target cells of aPL, bridge the gap between the molecular level of these antibodies and the tissue and organ level of pathological changes. A more in-depth exploration of the relationship between ECs and the pathogenesis of APS holds the potential for significant advancements in the precise diagnosis, classification, and therapy of APS. Many researchers have highlighted the vital involvement of ECs in APS and the underlying mechanisms governing their functionality. Through extensive in vitro and in vivo experiments, they have identified multiple aPL receptors on the EC membrane and various intracellular pathways. This article furnishes a comprehensive overview and summary of these receptors and signaling pathways, offering prospective targets for APS therapy.

show abstract

Section: Signaling Pathways In Endothelial Cellsmentioning

confidence: 99%