The mTOR Signaling Pathway and Regulation of Pancreatic Function

Williams, Maria Dolors Sans and John A.

doi:10.3998/panc.2017.08

Cited by 2 publications

(2 citation statements)

References 42 publications

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“…Although the mechanism of insulin signaling is well studied in a number of target tissues especially liver, fat and muscle, only a few studies have been carried out in the exocrine pancreas. The main signaling pathway regulating protein synthesis is the mTOR pathway and this pathway has been documented in pancreatic acinar cells primarily in mediating the actions of CCK and acetylcholine to stimulate digestive enzyme synthesis (266,326). Insulin has been shown to activate S6 kinase and S6 phosphorylation downstream of TORC1 in rat and mouse acini (33,290).…”

Section: Protein Synthesismentioning

confidence: 99%

Intermediate Filament Keratins in The Exocrine Pancreas

Alam¹,

Baghestani²,

Toivola³

Pancreapedia: Exocrine Pancreas Knowledge Base

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Section: Protein Synthesismentioning

confidence: 99%

Intermediate Filament Keratins in The Exocrine Pancreas

Alam¹,

Baghestani²,

Toivola³

Pancreapedia: Exocrine Pancreas Knowledge Base

View full text Add to dashboard Cite

“…Although the mechanism of insulin signaling is well studied in a number of target tissues, especially liver, fat and muscle, only a few studies have been carried out in the exocrine pancreas. The main signaling pathway regulating protein synthesis is the mTORC1 pathway and this pathway has been documented in pancreatic acinar cells primarily in mediating the actions of CCK and acetylcholine to stimulate digestive enzyme synthesis (164,213). Insulin has been shown to be involved in protein synthesis in several studies (13,98,107), and has nonparallel effects on translation of specific proteins (133).…”

Section: Insulinmentioning

confidence: 99%

Pancreatic Digestive Enzyme Synthesis and its Translational Control

Pancreapedia: Exocrine Pancreas Knowledge Base

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Protein synthesis plays a central role in provision of pancreatic digestive enzymes and the maintenance of the pancreas. Both the mRNA profile and relative content of newly synthesized proteins are dominated by digestive enzymes. In the mature pancreas, about 90% of protein synthesis has been estimated to be devoted to a mixture of about 20 digestive enzymes (204). Whether the acinar cell can regulate digestive enzyme synthesis independent of the synthesis of cellular structural proteins is unclear. Pancreatic protein synthesis is regulated to match digestive enzyme synthesis to dietary need. Although the identity of individual synthesized proteins and longterm regulation is primarily determined by transcriptional regulation, the short-term extent, or rate of protein synthesis, is regulated at the translational level (161), because it needs to be immediate, flexible and reversible (123).

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The mTOR Signaling Pathway and Regulation of Pancreatic Function

Cited by 2 publications

References 42 publications

Intermediate Filament Keratins in The Exocrine Pancreas

Intermediate Filament Keratins in The Exocrine Pancreas

Pancreatic Digestive Enzyme Synthesis and its Translational Control

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