The multi‐factorial modes of action of urease in the pathogenesis of incontinence associated dermatitis
Emily J. Owen,
Rachel A. Heylen,
Kyle Stewart
et al.
Abstract:BackgroundIncontinence Associated Dermatitis (IAD) is a type of skin inflammation caused by chronic exposure to urine and/or faeces. Current treatment strategies involve creating a barrier between the skin and urine/faeces rather than targeting specific irritants. Urease expressing pathogens catalyse the conversion of urea, present in urine, into ammonia. The accumulation of ammonia causes an elevation in skin pH which is believed to activate faecal enzymes which damage skin, and opportunistic pathogens, which… Show more
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