The multidimensional value of natriuretic peptides in heart failure, integrating laboratory and clinical aspects

Gruson, Damien; Hammerer-Lercher, Angelika; Collinson, Paul; Duff, Christopher; Baum, Hannsjörg; Pulkki, Kari; Suvisaari, Janne; Stankovic, Sanja; Laitinen, Paivi; Bayes-Genis, Antoni

doi:10.1080/10408363.2024.2319578

Critical Reviews in Clinical Laboratory Sciences

2024

DOI: 10.1080/10408363.2024.2319578

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The multidimensional value of natriuretic peptides in heart failure, integrating laboratory and clinical aspects

Damien Gruson,

Angelika Hammerer-Lercher,

Paul Collinson

et al.

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2024

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Cited by 3 publications

References 101 publications

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Circulating biomarkers of myocardial remodelling: current developments and clinical applications

López,

Ravassa,

San José

et al. 2024

Heart

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Myocardial remodelling, entailing cellular and molecular changes in the different components of the cardiac tissue in response to damage, underlies the morphological and structural changes leading to cardiac remodelling, which in turn contributes to cardiac dysfunction and disease progression. Since cardiac tissue is not available for histomolecular diagnosis, surrogate markers are needed for evaluating myocardial remodelling as part of the clinical management of patients with cardiac disease. In this setting, circulating biomarkers, a component of the liquid biopsy, provide a promising approach for the fast, affordable and scalable screening of large numbers of patients, allowing the detection of different pathological features related to myocardial remodelling, aiding in risk stratification and therapy monitoring. However, despite the advances in the field and the identification of numerous potential candidates, their implementation in clinical practice beyond natriuretic peptides and troponins is mostly lacking. In this review, we will discuss some biomarkers related to alterations in the main cardiac tissue compartments (cardiomyocytes, extracellular matrix, endothelium and immune cells) which have shown potential for the assessment of cardiovascular risk, cardiac remodelling and therapy effects. The hurdles and challenges for their translation into clinical practice will also be addressed.

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Circulating biomarkers of myocardial remodelling: current developments and clinical applications

López,

Ravassa,

San José

et al. 2024

Heart

View full text Add to dashboard Cite

show abstract

The value of natriuretic peptide testing for the diagnosis and prevention of heart failure in high-risk populations

Gruson

2024

Advances in Laboratory Medicine / Avances en Medicina De Laboratorio

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Valor del análisis de péptido natriurético en el diagnóstico y prevención de la insuficiencia cardíaca en poblaciones de alto riesgo

Gruson

2024

Advances in Laboratory Medicine / Avances en Medicina De Laboratorio

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The multidimensional value of natriuretic peptides in heart failure, integrating laboratory and clinical aspects

Cited by 3 publications

References 101 publications

Circulating biomarkers of myocardial remodelling: current developments and clinical applications

Circulating biomarkers of myocardial remodelling: current developments and clinical applications

The value of natriuretic peptide testing for the diagnosis and prevention of heart failure in high-risk populations

Valor del análisis de péptido natriurético en el diagnóstico y prevención de la insuficiencia cardíaca en poblaciones de alto riesgo

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