The Multifaceted Actions of Curcumin in Obesity

Bianconi, Vanessa; Pirro, Matteo; Moallem, Seyed Mohammad Hassan; Majeed, Muhammed; Bronzo, Paola; D’Abbondanza, Marco; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

doi:10.1007/978-3-030-73234-9_6

Cited by 7 publications

(5 citation statements)

References 106 publications

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“…Furthermore, not only are the molecular pathways sufficiently identifiable to rule out a placebo impact alone, but the relatively low cost of curcumin, plus its safety record and proven efficacy in multiple health spheres make it advisable to include curcumin as part of healthy diet. Bianconi et al 33 recently concluded that according to the existing literature, curcumin may regulate lipid metabolism, and suppress chronic inflammation and its interactions with white adipose tissue, which plays a central role in the complications associated with obesity, wherein curcumin appears to consistently inhibit the differentiation of adipocytes, while improving their anti-oxidant properties, a highly probable key to preventing and effectively mitigating against chronic diseases, 34 and obesity. 22 Generally supportive of this view is additional current research by Islam et al 35 showing curcumin does appear to exert protective metabolic effects in dietary obesity states, in part through the downregulation of adipose tissue inflammation, and metabolism of curcumin into curcumin-O-glucuronide, along with other mechanisms.…”

Section: Resultsmentioning

confidence: 99%

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Childhood obesity and curcumin: a possible effective anti-obesity adjunct

Marks¹

2022

AOWMC

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Obesity, a largely intractable health condition with incalculable health, financial and social costs and ramifications and often emerging in the context of early childhood and without amelioration thereafter, remains an immense challenge to mitigate effectively, despite years of study. Consequently, interventions that can limit the early onset of obesity, or help to reduce this to any degree where present, remain of high significance. Studied now for over 20 years, the role of spices such as turmeric that contains a yellow pigment known as curcumin, a derivative employed widely in Asian dietary and health contexts for centuries appears promising for purposes of combating obesity and its analogues such as diabetes. Based on available data, this mini review specifically discusses some findings regarding curcumin and obesity, and what has been observed to date. Extracted from current literature, it is concluded that this is a field of significant promise, but one requiring more research among young people as well as diverse obesity associated conditions across time.

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Section: Resultsmentioning

confidence: 99%

“…Schematic representation of possible benefits of curcumin supplementation in cases of intractable obesity or those at risk for obesity. 4,33,[35][36][37]40,42,56,57…”

Section: Figurementioning

confidence: 99%

Childhood obesity and curcumin: a possible effective anti-obesity adjunct

Marks¹

2022

AOWMC

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“…Obesity, characterized as the pathological hyperplasia or/and hypertrophy of adipose tissue, is one of the major contributing factors of metabolic syndrome. Curcumin could promote preadipocyte apoptosis as well as suppress adipocyte differentiation, and thus inhibiting adipogenesis [ 152 ]. An in vitro study reported that curcumin inhibited mitotic clonal expansion (MCE), reduced the activation of peroxisome proliferator-activated receptors (PPARγ) and CCAAT enhancer binding proteins (C/EBPα), as well as the lipid accumulation in 3T3-L1 adipocytes [ 153 ].…”

Section: The Pharmacological Mechanisms Of Curcuminmentioning

confidence: 99%

Pharmacological Mechanisms and Clinical Applications of Curcumin: Update

Hao¹,

Chu²,

Jing-xuan³

et al. 2023

Aging and disease

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Curcumin, a well-known hydrophobic polyphenol extracted from the rhizomes of turmeric (Curcuma longa L.), has attracted great interest in the last ten years due to its multiple pharmacological activities. A growing body of evidence has manifested that curcumin has extensive pharmacological activities including anti-inflammatory, anti-oxygenation, lipid regulation, antiviral, and anticancer with hypotoxicity and minor adverse reactions. However, the disadvantages of low bioavailability, short half-life in plasma, low drug concentration in blood, and poor oral absorption severely limited the clinical application of curcumin. Pharmaceutical researchers have carried out plenty of dosage form transformations to improve the druggability of curcumin and have achieved remarkable results. Therefore, the objective of this review summarizes the pharmacological research progress, problems in clinical application and the improvement methods of curcumin’s druggability. By reviewing the latest research progress of curcumin, we believe that curcumin has a broad clinical application prospect for its wide range of pharmacological activities with few side effects. The deficiencies of lower bioavailability of curcumin could be improved by dosage form transformation. However, curcumin in the clinical application still requires further study regarding the underlying mechanism and clinical trial verification.

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“…In a diabetes study, curcumin inhibited adipose STAT3 activation, which is essential for signaling in insulin resistance onset [29,30]. Moreover, recent studies reported that curcumin affected protection against obesity and gestational diabetes [31,32]. Surprisingly, when treated with Curcumae radix, glycolysis metabolism and neurodegenerative markers decreased in the mouse brain and ND model-tau overexpression mouse brain.…”

Section: Introductionmentioning

confidence: 97%

Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis Decrease and TCA Cycle Activation

Yang

Lee

et al. 2022

Nutrients

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Neurodegenerative diseases (ND) are being increasingly studied owing to the increasing proportion of the aging population. Several potential compounds are examined to prevent neurodegenerative diseases, including Curcumae radix, which is known to be beneficial for inflammatory conditions, metabolic syndrome, and various types of pain. However, it is not well studied, and its influence on energy metabolism in ND is unclear. We focused on the relationship between ND and energy metabolism using Curcumae radix extract (CRE) in cells and animal models. We monitored neurodegenerative markers and metabolic indicators using Western blotting and qRT-PCR and then assessed cellular glycolysis and metabolic flux assays. The levels of Alzheimer’s disease-related markers in mouse brains were reduced after treatment with the CRE. We confirmed that neurodegenerative markers decreased in the cerebrum and brain tumor cells following low endoplasmic reticulum (ER) stress markers. Furthermore, glycolysis related genes and the extracellular acidification rate decreased after treatment with the CRE. Interestingly, we found that the CRE exposed mouse brain and cells had increased mitochondrial Tricarboxylic acid (TCA) cycle and Oxidative phosphorylation (OXPHOS) related genes in the CRE group. Curcumae radix may act as a metabolic modulator of brain health and help treat and prevent ND involving mitochondrial dysfunction.

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The Multifaceted Actions of Curcumin in Obesity

Cited by 7 publications

References 106 publications

Childhood obesity and curcumin: a possible effective anti-obesity adjunct

Childhood obesity and curcumin: a possible effective anti-obesity adjunct

Pharmacological Mechanisms and Clinical Applications of Curcumin: Update

Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis Decrease and TCA Cycle Activation

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