The multifaceted role of oestrogen in enhancing Chlamydia trachomatis infection in polarized human endometrial epithelial cells

Hall, Jennifer V.; Schell, Maria; Dessus-Babus, Sophie; Moore, Cheryl G.; Whittimore, Judy D.; Sal, Melanie; Dill, Brian D.; Wyrick, Priscilla B.

doi:10.1111/j.1462-5822.2011.01608.x

Cited by 27 publications

(33 citation statements)

References 53 publications

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“…C. trachomatis development and replication in vivo may be subject to stresses imposed by nutritional requirements 142, innate and adaptive immune responses 143, host physiology via hormones 144145146 and even competition with commensals or co-pathogens 147148. Conditions that delay bacterial multiplication impair effectiveness of antibiotics in many microorganisms 149150151.…”

Section: Treatment and Preventionmentioning

confidence: 99%

Chlamydia trachomatis Genital Infections

O’Connell¹,

Ferone²

2016

MIC

174

153

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Etiology, transmission and protection: Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infection (STI) globally. However, C. trachomatis also causes trachoma in endemic areas, mostly Africa and the Middle East, and is a leading cause of preventable blindness worldwide. Epidemiology, incidence and prevalence: The World Health Organization estimates 131 million new cases of C. trachomatis genital infection occur annually. Globally, infection is most prevalent in young women and men (14-25 years), likely driven by asymptomatic infection, inadequate partner treatment and delayed development of protective immunity. Pathology/Symptomatology: C. trachomatis infects susceptible squamocolumnar or transitional epithelial cells, leading to cervicitis in women and urethritis in men. Symptoms are often mild or absent but ascending infection in some women may lead to Pelvic Inflammatory Disease (PID), resulting in reproductive sequelae such as ectopic pregnancy, infertility and chronic pelvic pain. Complications of infection in men include epididymitis and reactive arthritis. Molecular mechanisms of infection: Chlamydiae manipulate an array of host processes to support their obligate intracellular developmental cycle. This leads to activation of signaling pathways resulting in disproportionate influx of innate cells and the release of tissue damaging proteins and pro-inflammatory cytokines. Treatment and curability: Uncomplicated urogenital infection is treated with azithromycin (1 g, single dose) or doxycycline (100 mg twice daily x 7 days). However, antimicrobial treatment does not ameliorate established disease. Drug resistance is rare but treatment failures have been described. Development of an effective vaccine that protects against upper tract disease or that limits transmission remains an important goal.

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Section: Treatment and Preventionmentioning

confidence: 99%

Chlamydia trachomatis Genital Infections

O’Connell¹,

Ferone²

2016

MIC

174

153

View full text Add to dashboard Cite

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“…Clearance of C. trachomatis infection might be delayed by pathogen immune evasion strategies such as enhanced survival inside and outside host cells, reduced inflammatory and adaptive immune responses and ability to persist within host cells as AB [39]. Adding complexity, sex hormones modulate female genital tract immune responses 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 647 [40,41]. Women are more susceptible to chlamydial infection under the influence of estradiol, and estradiol enhances disease sequelae [40].…”

Section: Chlamydia Trachomatis: Genital Infectionsmentioning

confidence: 99%

Chronic Chlamydial Diseases: From Atherosclerosis to Urogenital Infections

Leonard

Borel

2014

Curr Clin Micro Rpt

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Chlamydiae cause a wide range of diseases in human and animal hosts. Chlamydia pneumoniae and Chlamydia trachomatis are important human pathogens with worldwide distribution that produce significant morbidity. Acute infections with C. pneumoniae cause respiratory tract infections, while chronic infection has been linked to chronic bronchitis, asthma and atherosclerosis. Ocular serovars of C. trachomatis induce trachoma, the leading cause of infectious blindness worldwide. C. trachomatis is the most common bacterial cause of sexually transmitted diseases (STDs) worldwide. Acute infections with genital serovars of C. trachomatis remain clinically silent in most women, but can progress to upper genital tract infection leading to pelvic inflammatory disease (PID), infertility and ectopic pregnancy. Chlamydiainduced, reactive arthritis can develop as a late-term condition after genital C. trachomatis or respiratory C. pneumoniae infection. In this review, we address recent information on pathogenesis, immune response, diagnosis and treatment of chronic diseases induced by C. trachomatis and C. pneumoniae. Abstract:Chlamydiae cause a wide range of diseases in human and animal hosts. Chlamydia pneumoniae and Chlamydia trachomatis are important human pathogens with worldwide distribution that produce significant morbidity. Acute infections with C. pneumoniae cause respiratory tract infections, while chronic infection has been linked to chronic bronchitis, asthma and atherosclerosis. Ocular serovars of C. trachomatis induce trachoma, the leading cause of blindness worldwide. C. trachomatis is the most common bacterial cause of sexually-transmitted diseases (STDs) worldwide. Acute infections with genital serovars of C. trachomatis remain clinically silent in most women but can progress to upper genital tract infection leading to pelvic inflammatory disease (PID), infertility and ectopic pregnancy. Chlamydia-induced, reactive arthritis can develop as a late-term condition after genital C. trachomatis or respiratory C. pneumoniae infection. In this review we address recent information on pathogenesis, immune

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“…Accordingly, estrogen and progesterone are important for the establishment of chlamydial infection. Furthermore, estrogen receptors have been involved in the internalization of CT [92,93]. Sex hormones affect the clinical outcome of chlamydial infections; thus, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P4), and prolactin (PRL) are involved not only in the establishment of chlamydial infection but also in the development of sequelae on reproductive tissue [94,95].…”

Section: Age and Hormonal Statusmentioning

confidence: 99%

Female Infertility Associated to Chlamydia trachomatis Infection

Lujan¹,

Fili²,

Damiani³

2016

Genital Infections and Infertility

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Chlamydia trachomatis (CT) is the most common agent of bacterial sexually transmitted infections, both in developed and developing countries. It clearly constitutes a major burden on public health. Screening programs and current research are mainly focused on decreasing the high incidence of chlamydial infections as well as their associated morbidity. The greater clinical impact of CT infections occurs in women of reproductive age. Acute CT infections are often associated to urethritis, mucopurulent cervicitis, endometritis, salpingitis, and pelvic inflammatory disease (PID). A vast proportion of CT infections are likely underestimated because of their asymptomatic clinical course. This leads to repeat and chronic infections, which have deleterious impact on the female reproductive health. Among the complications of the CT chronic infections are PID, ectopic pregnancy, preterm birth, tubal obstruction and female infertility, which are of great interest in the reproduction field.

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The multifaceted role of oestrogen in enhancing Chlamydia trachomatis infection in polarized human endometrial epithelial cells

Cited by 27 publications

References 53 publications

Chlamydia trachomatis Genital Infections

Chlamydia trachomatis Genital Infections

Chronic Chlamydial Diseases: From Atherosclerosis to Urogenital Infections

Female Infertility Associated to Chlamydia trachomatis Infection

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