The Multifunction Role of Tumor-Associated Mesenchymal Stem Cells and Their Interaction with Immune Cells in Breast Cancer

Chauhan, Anita; Agarwal, Sonam; Masih, Marilyn; Gautam, Pramod Kumar

doi:10.1080/08820139.2023.2249025

Cited by 8 publications

(5 citation statements)

References 120 publications

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Section: Cancer Stem Cells Origin and Propertiesmentioning

confidence: 99%

“…Aside glioblastoma, MSCs have been proposed as potential cells-of-origin for CSCs in various other cancer types, including breast cancer (36,37), prostate cancer (38), and osteosarcoma (37,39). The capacity of MSCs to differentiate into multiple lineages and their inherent migratory and self-renewal properties may contribute to their potential role in CSC formation and tumor progression (33,34,36,37). The role of MSCs as cells-of-origin for CSCs is an active area of research, and further investigation is needed to elucidate the mechanisms underlying this potential relationship and its implications for cancer development and therapeutic strategies.…”

Section: Cancer Stem Cells Origin and Propertiesmentioning

confidence: 99%

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The intricate interplay between cancer stem cells and cell-of-origin of cancer: implications for therapeutic strategies

Bamodu,

Chung,

Pisanic

et al. 2024

Front. Oncol.

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BackgroundCancer stem cells (CSCs) have emerged as pivotal players in tumorigenesis, disease progression, and resistance to therapies.ObjectiveThis comprehensive review delves into the intricate relationship between CSCs and the cell-of-origin in diverse cancer types.DesignComprehensive review of thematically-relevant literature.MethodsWe explore the underlying molecular mechanisms that drive the conversion of normal cells into CSCs and the impact of the cell-of-origin on CSC properties, tumor initiation, and therapeutic responses. Moreover, we discuss potential therapeutic interventions targeting CSCs based on their distinct cell-of-origin characteristics.ResultsAccruing evidence suggest that the cell-of-origin, the cell type from which the tumor originates, plays a crucial role in determining the properties of CSCs and their contribution to tumor heterogeneity.ConclusionBy providing critical insights into the complex interplay between CSCs and their cellular origins, this article aims to enhance our understanding of cancer biology and pave the way for more effective and personalized cancer treatments.

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Section: Cancer Stem Cells Origin and Propertiesmentioning

confidence: 99%

Section: Cancer Stem Cells Origin and Propertiesmentioning

confidence: 99%

The intricate interplay between cancer stem cells and cell-of-origin of cancer: implications for therapeutic strategies

Bamodu,

Chung,

Pisanic

et al. 2024

Front. Oncol.

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“…Mesenchymal stem cells (MSCs), a type of pluripotent progenitor cells, possess multifunctional properties such as tissue regeneration and self-renewal ( 153 ). They exhibit the capacity to differentiate into various cell lineages, including OBs, chondrocytes, and adipocytes ( 154 ).…”

Section: Roles Of Ifn-γ In Opmentioning

confidence: 99%

Osteoporosis: interferon-gamma-mediated bone remodeling in osteoimmunology

Li,

Liu,

2024

Front. Immunol.

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As the world population ages, osteoporosis, the most common disease of bone metabolism, affects more than 200 million people worldwide. The etiology is an imbalance in bone remodeling process resulting in more significant bone resorption than bone remodeling. With the advent of the osteoimmunology field, the immune system’s role in skeletal pathologies is gradually being discovered. The cytokine interferon-gamma (IFN-γ), a member of the interferon family, is an important factor in the etiology and treatment of osteoporosis because it mediates bone remodeling. This review starts with bone remodeling process and includes the cellular and key signaling pathways of bone remodeling. The effects of IFN-γ on osteoblasts, osteoclasts, and bone mass are discussed separately, while the overall effects of IFN-γ on primary and secondary osteoporosis are summarized. The net effect of IFN-γ on bone appears to be highly dependent on the environment, dose, concentration, and stage of cellular differentiation. This review focuses on the mechanisms of bone remodeling and bone immunology, with a comprehensive discussion of the relationship between IFN-γ and osteoporosis. Finding the paradoxical balance of IFN-γ in bone immunology and exploring the potential of its clinical application provide new ideas for the clinical treatment of osteoporosis and drug development.

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“…Mesenchymal stem cells (MSCs) can differentiate into adipocytes, osteoblasts, and chondrocytes, among other mesodermal lineages 38 . As a result of their ability to modulate the tumor microenvironment (TME), MSCs have received considerable attention in recent years [39][40][41] . It is important to note that MSCs have a dual nature when used to treat cancer.…”

Section: Cancer Stem Cells Origin and Mechanism Of Actionmentioning

confidence: 99%

In Vivo Stem Cell Discoveries: Promising Implications in Cancer Therapy

Gevargiz Sangar,

Agahi,

Azizi

et al. 2023

J Lab Anim. Res

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The remarkable regenerative abilities and versatility of stem cells have long attracted researchers. Recently, in vivo studies have revealed exciting results related to stem cells, particularly their use in cancer treatment. This review will provide an overview of these discoveries and their broader implications for the future. There is growing in vivo evidence that stem cells have immense therapeutic potential in treating various diseases, including cancer, because of their self-renewal and differentiation capabilities. As a result of in vivo research, critical aspects of stem cell behavior within tumor microenvironments have been clarified, providing a deeper understanding of their potential therapeutic utility. Several in vivo studies have demonstrated the potential of stem cell-engineered tumor-targeting agents or therapeutic payloads for the precise delivery of medicinal drugs when these agents are engineered to express them in tumor cells. Through targeted therapies, off-target effects can be minimized, and the therapeutic index of the anti-cancer agents can be improved. Several stem cell-based delivery systems have shown remarkable efficacy in preclinical in vivo studies, including breast, lung, and pancreatic cancer, indicating their potential as a novel therapeutic strategy. Moreover, in vivo studies have revealed that the immunomodulatory properties of stem cells modulate the immune response and modify the tumor microenvironment to suppress it. In particular, using checkpoint inhibitor therapy with stem cells has paved the way for innovative immunotherapeutic strategies. Research on stem cells in vivo has also provided invaluable insights into stem cell biology and their interaction with cancer cells. Due to these findings, there is an increasing understanding of tumor initiation, progression, and resistance mechanisms, which has opened avenues for improving cancer treatment by developing more effective treatments. As a result of the in vivo studies that have taken place so far, there is a wealth of information regarding the potential of stem cells in cancer treatment. This research opens up exciting prospects for the future of oncology, from the delivery of targeted drugs to immunomodulation and improving our understanding of tumor biology.

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The Multifunction Role of Tumor-Associated Mesenchymal Stem Cells and Their Interaction with Immune Cells in Breast Cancer

Cited by 8 publications

References 120 publications

The intricate interplay between cancer stem cells and cell-of-origin of cancer: implications for therapeutic strategies

The intricate interplay between cancer stem cells and cell-of-origin of cancer: implications for therapeutic strategies

Osteoporosis: interferon-gamma-mediated bone remodeling in osteoimmunology

In Vivo Stem Cell Discoveries: Promising Implications in Cancer Therapy

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