The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population

Abstract

Hypertension (HTN) and osteoarthritis (OA) are frequent in middle-aged and elderly people, and the co-occurrence of these two diseases is common. However, the pathogenesis of the multimorbidity of both diseases and the relation with sleep quality, hyperlipemia, and hyperglycemia is unclear. We conducted a cross-sectional study to make sense of the multimorbidity of HTN and OA and the relation with sleep quality, hyperlipemia, and hyperglycemia. The relation between sleep quality and OA and its joint effect with hyperlipemia or hyperglycemia was evaluated with logistic regression models. The additive interaction was assessed with the relative excess risk due to interaction (REEI), the attributable proportion (AP), and the synergy index (S). According to this research in a remote rural area, approximately 34.2% of HTN patients are accompanied with OA and 49.1% are suffering poor sleep. Both hyperlipemia/hyperglycemia and sleep quality were related to OA prevalence with crude ORs of 1.43 (95% CI 1.014–2.029) and 1.89 (95% CI 1.411–2.519, P < 0.001) respectively. An observed additive effect was found greater than the sum of the effects of sleep quality and hyperlipemia/hyperglycemia posed on OA prevalence alone. This additive interaction was observed in females (OR = 3.19, 95% CI 1.945–5.237) as well as males ≥ 65 years old (OR = 2.78, 95% CI 1.693–4.557), with RERI, AP, and S significant. Therefore, poor sleep and hyperlipemia/hyperglycemia are associated with OA, and further studies on the additive interaction among females and males ≥ 65 are warranted.

Effects of Work Stress and Period3 Gene Polymorphism and Their Interaction on Sleep Quality of Non-Manual Workers in Xinjiang, China: A Cross-Sectional Study

“…Currently, sleep quality problems have become a more common health problem. Sleep quality problems can cause adverse effects such as drowsiness and fatigue, easily trigger psychological problems such as anxiety and depression, and increase the risk of cardiovascular diseases such as hypertension and coronary heart disease and death [ 29 , 30 , 31 , 32 , 33 ]. Therefore, it is particularly important to develop targeted preventive and intervention measures for non-manual workers in Xinjiang to improve their sleep quality.…”

Interaction between rheumatoid arthritis and mediterranean diet on the risk of cardiovascular disease for the middle aged and elderly from National Health and Nutrition Examination Survey (NHANES)

“…The definition of CVD was based on the self-reported questions: Ever told you had congestive heart failure/ coronary heart disease/angina/angina pectoris/heart attack/stroke. Participants who answered “yes” to the question were defined as having CVD [ 22 ].…”

Relationship between physical activity, sleep quality, and frailty in middle-aged and older adults: a cross-sectional study Running title: The correlation between physical activity, sleep quality, and frailty

“…Sleep, a fundamental physiological necessity for the human body, plays a crucial role in overall health. Sleep-related issues affect over half of middle-aged and older adults (19), and the persistence of poor sleep quality contributes to the onset of numerous diseases (20,21). Consequently, sleep problems have become a prevalent concern among this demographic.…”