The Multiple Actions of the Insulin-Like Growth Factor-I Signaling in the Myocardium

Philippou, Αnastassios; Maridaki, Μaria; Karatzas, Theodore; Koutsilieris, Michael

doi:10.1007/978-3-319-08798-6_11

Cited by 10 publications

(11 citation statements)

References 87 publications

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“…[ 56, 57 ] IGFs (notably IGF‐1) are particularly important and their potential to induce and sustain muscle growth has been repeatedly demonstrated in a number of studies. [ 56–63 ] The major role of IGF‐1 signaling in muscle hypertrophy is beyond the scope and has been reviewed elsewhere (e.g., Refs. [57, 63–65]); however, several key points will be emphasized for clarity.…”

Section: Hypothesis: D‐galactose Plays a Role In Skeletal Muscle Hype...mentioning

confidence: 99%

D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?

Homolak,

Babic Perhoc,

Virag

et al. 2023

BioEssays

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Sarcopenia is a process of progressive aging‐associated loss of skeletal muscle mass (SMM) recognized as a serious global health issue contributing to frailty and increased all‐cause mortality. Exercise and nutritional interventions (particularly intake of dairy products and milk) demonstrate good efficacy, safety, and broad applicability. Here, we propose that at least some of the well‐documented favorable effects of milk and milk‐derived protein supplements on SMM might be mediated by D‐galactose, a monosaccharide present in large quantities in milk in the form of disaccharide lactose (milk sugar). We suggest that ingestion of dairy products results in exposure to D‐galactose in concentrations metabolized primarily via the Leloir pathway with the potential to (i) promote anabolic signaling via maintenance of growth factor (e.g., insulin‐like growth factor 1 [IGF‐1]) receptor mature glycosylation patterns; and (ii) provide extracellular (liver glycogen) and intracellular substrates for short (muscle glycolysis) and long‐term (muscle glycogen, intramyocellular lipids) energy availability. Additionally, D‐galactose might optimize the metabolic function of skeletal muscles by increasing mitochondrial content and stimulating glucose and fatty acid utilization. The proposed potential of D‐galactose to promote the accretion of SMM is discussed in the context of its therapeutic potential in sarcopenia.

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Section: Hypothesis: D‐galactose Plays a Role In Skeletal Muscle Hype...mentioning

confidence: 99%

D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?

Homolak,

Babic Perhoc,

Virag

et al. 2023

BioEssays

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“…Previous studies have provided evidence that local production of IGF-1 requires isoform-specific (extension) E peptides to drive hypertrophy in growing skeletal muscle and that both common and unique pathways exist for IGF-1 isoforms to promote biological effects [11,31]. There has been increasing interest in the differential expression and implication of IGF-1 isoforms in the regulation of muscle fiber regeneration and hypertrophy following mechanical overloading and damage [32]. Interestingly, however, there is no study to date providing insight on the role of IGF-1 isoforms in the development of smooth muscle hypertrophy and hyperplasia, especially in the context of deep infiltrative endometriotic nodules.…”

Section: Discussionmentioning

confidence: 99%

Differential Expression of Insulin Growth Factor 1 (IGF-1) Isoforms in Different Types of Endometriosis: Preliminary Results of a Single-Center Study

Blontzos,

Mavrogianni,

Ntzeros

et al. 2023

Biomolecules

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Endometriosis is a benign, estrogen-dependent gynecological condition with an uncertain exact pathogenetic mechanism. The aim of this study was to evaluate the potential differential expression of Insulin Growth Factor 1 (IGF-1) isoforms in deeply infiltrating endometriotic (DIE) lesions, in ovarian endometriomas, and in the eutopic endometrium of the same endometriosis patients and to compare their expression with that in the eutopic endometrium of women without endometriosis. A total of 39 patients were included: 28 with endometriosis, of whom 15 had endometriomas only, 7 had DIE nodules only, and 6 had both DIE and endometriomas, and 11 without endometriosis served as controls. We noticed a similar pattern of expression between IGF-1Ea and IGF-1Ec, which differed from that of the IGF-1Eb isoform, possibly implying differential biological actions of different isoforms in DIE subtypes. We observed a tendency of lower expression of IGF-1Ea and IGF-1Ec in endometriomas without DIE compared to endometriomas with concurrent DIE or in DIE nodules. In conclusion, differential expression of IGF-1 isoforms may indicate that DIE with its associated ovarian lesions and simple ovarian endometriosis should be considered as two forms of the disease developing under different molecular pathways.

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“…Mechanical loading of skeletal and cardiac muscle cells can induce the upregulation of many growth factors associated with protein synthesis and cell growth, eventually leading to muscle hypertrophy [27,30,44,57,58]. In particular, the upregulation of IGF-1 has been implicated in the adaptive cardiac hypertrophy induced by mechanical loading, while potentially differential actions of IGF-1 isoforms in the myocardial repair/remodelling process have been proposed [26,59]. Our findings showed that both isoforms were upregulated by low-frequency stretching protocols, while strain appeared to regulate the magnitude of overexpression, with more pronounced increases being exhibited after the high-strain/low-frequency protocol and vice versa.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Mechanical Loading Variations on the Hypertrophic, Anti-Apoptotic, and Anti-Inflammatory Responses of Differentiated Cardiomyocyte-like H9C2 Cells

Zevolis

Philippou

Moustogiannis

et al. 2022

Cells

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Cardiomyocytes possess the ability to respond to mechanical stimuli by adapting their biological functions. This study investigated cellular and molecular events in cardiomyocyte-like H9C2 cells during differentiation as well as the signalling and gene expression responses of the differentiated cells under various mechanical stretching protocols in vitro. Immunofluorescence was used to monitor MyHC expression and structural changes during cardiomyoblast differentiation. Moreover, alterations in the expression of cardiac-specific markers, cell cycle regulatory factors, MRFs, hypertrophic, apoptotic, atrophy and inflammatory factors, as well as the activation of major intracellular signalling pathways were evaluated during differentiation and under mechanical stretching of the differentiated H9C2 cells. Compared to undifferentiated cells, advanced-differentiation cardiomyoblasts exhibited increased expression of cardiac-specific markers, MyHC, MRFs, and IGF-1 isoforms. Moreover, differentiated cells that underwent a low strain/frequency mechanical loading protocol of intermediate duration showed enhanced expression of MRFs and hypertrophic factors, along with a decreased expression of apoptotic, atrophy, and inflammatory factors compared to both high-strain/frequency loading protocols and to unloaded cells. These findings suggest that altering the strain and frequency of mechanical loading applied on differentiated H9C2 cardiomyoblasts can regulate their anabolic/survival program, with a low-strain/frequency stretching being, overall, most effective at inducing beneficial responses.

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The Multiple Actions of the Insulin-Like Growth Factor-I Signaling in the Myocardium

Cited by 10 publications

References 87 publications

D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?

D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?

Differential Expression of Insulin Growth Factor 1 (IGF-1) Isoforms in Different Types of Endometriosis: Preliminary Results of a Single-Center Study

The Effects of Mechanical Loading Variations on the Hypertrophic, Anti-Apoptotic, and Anti-Inflammatory Responses of Differentiated Cardiomyocyte-like H9C2 Cells

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