2013
DOI: 10.3390/ijms14046542
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The Multiple Faces of Prostaglandin E2 G-Protein Coupled Receptor Signaling during the Dendritic Cell Life Cycle

Abstract: Many processes regulating immune responses are initiated by G-protein coupled receptors (GPCRs) and report biochemical changes in the microenvironment. Dendritic cells (DCs) are the most potent antigen-presenting cells and crucial for the regulation of innate and adaptive immune responses. The lipid mediator Prostaglandin E2 (PGE2) via four GPCR subtypes (EP1-4) critically regulates DC generation, maturation and migration. The role of PGE2 signaling in DC biology was unraveled by the characterization of EP rec… Show more

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Cited by 35 publications
(33 citation statements)
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“…Therefore, EP4 signaling may play a major role in promoting myoblast proliferation induced by PGE 2 . Next, a concentration-dependent effect of EP4 antagonist L161,982 (10,20, and 30 mM) on myoblast proliferation was tested. At 24 and 48 h, L161,982 dose-dependently inhibited myoblast proliferation (Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Therefore, EP4 signaling may play a major role in promoting myoblast proliferation induced by PGE 2 . Next, a concentration-dependent effect of EP4 antagonist L161,982 (10,20, and 30 mM) on myoblast proliferation was tested. At 24 and 48 h, L161,982 dose-dependently inhibited myoblast proliferation (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…18,19 Nevertheless, the roles of EP subtypes in cell proliferation are different, and could be cell type-dependent. [20][21][22][23][24] To study the role of PGE 2 in myoblast proliferation, the expression of EPs in mouse primary myoblasts was determined showing that all EPs are expressed in myoblasts. However, PGE 2 along with only an agonist for the EP4 receptor promoted myoblast proliferation, whereas EP1/3 and EP2 agonists did not show any significant effects.…”
Section: Introductionmentioning
confidence: 99%
“…Unlike EP2, EP4 can also be coupled to b-arrestin and b-catenin (Yokoyama et al, 2013). This explains the formation of an EP4/b-arrestin 1/cSrc signaling complex that plays an important role in cancer cell migration (Kim et al, 2010) and in DC function (De Keijzer et al, 2013). EP1 is coupled to a yet unknown G protein, but binding of PGE 2 to this receptor type leads to a transient increase in intracellular Ca 21 concentration and to activation of PLCb, presumably by coupling to a Ga q protein.…”
Section: Eicosanoids In Innate Immunitymentioning
confidence: 99%
“…4 They are also reported to be expressed in the renal system and immune system. 18,23 To analyze the safety profile of GW627368X as a drug, various biochemical tests were performed. In animals with solid subcutaneous tumors, normal activity and movement are restricted because of the asymmetric tumor outgrowth.…”
Section: Discussionmentioning
confidence: 99%