The multiple faces of the partial thromboplastin time APTT

Abstract

References

Coagulation Assays

“…17 However, evidence supporting the concept of an aPTT therapeutic range that predicts efficacy and safety (with respect to bleeding) is somewhat tenuous. 28 Approximately 25% of patients require doses of heparin of Ͼ35 000 U/d to obtain a therapeutic aPTT and are called heparin resistant. 29 Most of these patients have therapeutic heparin levels when measured with the anti-Xa assay, and the discrepancy between the 2 tests is the result of high concentrations of procoagulants such as fibrino- Factor Xa heparin assay.…”

A further face of the partial thromboplastin time APTT

“…The value of the activated partial thromboplastin time (APTT) has been well described by the Forum authors in relation to its clot–endpoint determination [1–6]. Its performance also has added value and enabled our group to unravel the existence of a calcium‐dependent complex between C‐reactive protein (CRP) and very low‐density lipoprotein (VLDL) [7].…”