The Multiple Functions of Macrophages in Immunity

Gottlieb, Allan; Waldman, Stephen R.; Adler, Frank L.

doi:10.3109/10408417209103870

Cited by 12 publications

(7 citation statements)

References 152 publications

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“…In recent years macrophages have been implicated in the execution of specific immune mechanisms (Gottlieb & Waldman, 1972). The following properties and functions of macrophages have been outlined though much work is still in progress and the exact part played by macrophages in immunity is still to be revealed: It has been customary to refer to the fixed phagocytic cells, indistinguishable in origin and function from the freely mobile tissue macrophages, as reticulo-endothelial (RE) cells.…”

Section: The Macrophagementioning

confidence: 99%

“…Monocytes are regarded as being immature cells which are thought not to proliferate further, i.e. are partially differentiated end cells (Gottlieb & Waldman, 1972). They reach their full maturity as cells when they leave the circulation and enter the tissues where they develop into macrophages.…”

Section: Function and Propertiesmentioning

confidence: 99%

“…Since Metchnikoff in 1882, from his studies on starfish larvae, it has been known that macrophages have great importance as scavengers of dead and foreign material. In recent years macrophages have been implicated in the execution of specific immune mechanisms (Gottlieb & Waldman, 1972). The following properties and functions of macrophages have been outlined though much work is still in progress and the exact part played by macrophages in immunity is still to be revealed:…”

Section: The Macrophagementioning

confidence: 99%

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The leucocytes of fish: A review

Ellis

1977

Journal of Fish Biology

487

289

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The data available in the literature concerning fish thrombocytes, lymphocytes, monocytes, macrophages and granulocytes is discussed and the dearth of reliable information concerning the functional identity of most fish leucocytes is underlined. The methods of applying nomenclatures to fish leucocytes encountered in thc literature is discussed in some detail and found to be unsatisfactory. An attempt is made to simplify the confused and conflicting reports by applying the concepts which have recently arisen in the field of mammalian immunology. Nomenclatures are assigned to cells on a functional and morphological basis where sufficient data exists.Thrombocytes are responsible for clot formation and are considered to be distinct, separate and unrelated to lymphocytes. Lymphocytes are recognised as immuno-competent cells though as yet little information exists on their role in immune mechanisms. Recent work is furnishing interesting results in this direction, especially in the origin of lymphocyte populations and their co-operative responses in immunity. Previous references to monocytes and macrophages in fish are confused and the literature is discussed in the light of the new classification of the Mononuclear Phagocyte System.Very few experimental data exist concerning granulocytic leucocytes in fish, indeed the presence of such cells with granulocytic functions still requires proof. Cells with morphological similarity to mammalian granulocytes do exist in fish but information essential for an understanding of their role in defence mechanisms is lacking. The state of the literature concerning the eosinophil, basophil and mast cell in fish is so confused that an entirely new approach to a study of these cells is warranted. It is hoped that this review will supply guidelines for future research.

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Section: The Macrophagementioning

confidence: 99%

Section: Function and Propertiesmentioning

confidence: 99%

Section: The Macrophagementioning

confidence: 99%

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The leucocytes of fish: A review

Ellis

1977

Journal of Fish Biology

487

289

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“…PCs were suspended in balanced salt solution to a concentration of 1 x 107 cells/mil and irradiated with 2,500 rads by using a Norelco MG150 X-ray machine (Phillips Electronics Instrument Co., N.Y.). The dose rate was 187 rads/min at 150 kV, 10 mA, and a focal distance of 40 cm. Assay for PFC.…”

mentioning

confidence: 99%

Immunodepression in Taenia crassiceps infection: restoration of the in vitro response to sheep erythrocytes by activated peritoneal cells

Miller¹,

Good²,

Mishell³

1978

Infect Immun

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The in vitro response to sheep erythrocytes of mesenteric lymph node cells from mice infected with the larval cestode Taenia crassiceps is significantly depressed and can be restored to control levels by addition of activated peritoneal cells depleted of functional T or B lymphocytes. Adherent mesenteric lymph node cells from infected mice are unable to reconstitute the in vitro response to sheep erythrocytes of normal nonadherent cells. The responses of mesenteric lymph node cells from infected mice to the T-lymphocyte mitogens concanavalin A and phytohemagglutinin and the B-lymphocyte mitogen lipopolysaccharide are normal. Mesenteric lymph node cells from infected mice do not suppress the in vitro response to sheep erythrocytes of normal mesenteric lymph node cells. These results suggest that the immunodepression in T. crassiceps-infected mice is primarily the result of alterations in functional accessory cells.

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“…Macrophage-lymphocyte interactions are also very important in both inductive ana effector stages of specific iiiiiiiuiic respGnses (Gottlieb and Waldman, 1972;Nossal and Ada, 1971;Unanue, 1972;Schwartz et al, 1970).…”

Section: Phagocytosismentioning

confidence: 99%

Cell-mediated immune responses in cattle

Reggiardo

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The Multiple Functions of Macrophages in Immunity

Cited by 12 publications

References 152 publications

The leucocytes of fish: A review

The leucocytes of fish: A review

Immunodepression in Taenia crassiceps infection: restoration of the in vitro response to sheep erythrocytes by activated peritoneal cells

Cell-mediated immune responses in cattle

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