The Multiple Interactions of RUNX with the Hippo–YAP Pathway

Chuang, Linda Shyue Huey; Ito, Yoshiaki

doi:10.3390/cells10112925

Cited by 25 publications

(18 citation statements)

References 106 publications

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“…Of these six genes, we identified Runx1 as an interesting candidate as it has been used as a marker of cardiomyocyte regression to a less differentiated state prior to cell cycle re-entry (D’Uva et al, 2015; Kubin et al, 2011). In addition, Runx1 has been shown to interact with Yap (Chuang and Ito, 2021), a transcription factor well established for its regulation of cardiomyocyte proliferation (Monroe et al, 2019). With this in mind, we first asked if Runx1-positive cardiomyocytes were more prevalent in A/J versus C57Bl/6J hearts at P21, just preceding expansion of the MNDCM population in A/Js.…”

Section: Resultsmentioning

confidence: 99%

Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds

Swift

Purdy

Kolell

et al. 2022

Preprint

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Somatic polyploidization, an adaptation by which cells increase their DNA content to support cell and organ growth, is observed in many mammalian cell types, including cardiomyocytes. Although polyploidization is beneficial in many contexts, progression to a polyploid state is often accompanied by a loss of proliferative capacity. Recent work suggests that heterogeneity in cardiomyocyte ploidy is highly influenced by genetic diversity. However, the developmental course by which cardiomyocytes reach their final ploidy state has only been investigated in select genetic backgrounds. Here, we assessed cardiomyocyte number, cell cycle activity, and ploidy dynamics across two divergent inbred mouse strains; C57Bl/6J and A/J. Both strains are born and reach adulthood with a comparable number of cardiomyocytes, however the end composition of ploidy classes and developmental progression to reach the final state and number differ substantially. In addition to corroborating previous findings that identified Tnni3k as a mediator of cardiomyocyte ploidy, we also uncover a novel role for Runx1 and Tnni3k in ploidy dynamics and cardiomyocyte cytokinesis. These data provide novel insight into the developmental path to cardiomyocyte ploidy states and challenge the paradigm that polyploidization and hypertrophy are the only mechanisms for growth in the mouse heart after the first week of life.

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Section: Resultsmentioning

confidence: 99%

Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds

Swift

Purdy

Kolell

et al. 2022

Preprint

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“…Although falling outside of the scope of this review, Runx has been widely demonstrated to be related to tumor development, cancer progression, and metastasis in different organs [ 26 , 27 ].…”

Section: Runx and Energy Statementioning

confidence: 99%

Association between Molecular Mechanisms and Tooth Eruption in Children with Obesity

2022

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Different works have reported earlier permanent teething in obese/overweight children compared to control ones. In contrast, others have reported a delayed permanent teething in undernutrition/underweight children compared to control one. It has been reported that becoming overweight or suffering from obesity can increase gingival pro-inflammatory drive and can affect orthodontic treatment (among other complications). In this sense, little is known about the molecular mechanisms affecting dental eruption timing. Leptin and adiponectin are adipocytokines signaling molecules released in overweight and underweight conditions, respectively. These adipocytokines can modulate osteocyte, odontoblast, and cementoblast activity, even regulating dental lamina initiation. The present review focuses on the molecular approach wherein leptin and adiponectin act as modulators of Runt-related transcription factor 2 (Runx 2) gene regulating dental eruption timing.

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“…Activated LATS1/2 and MOB1 in turn together phosphorylate the main effectors of the Hippo pathway, YAP and transcriptional coactivator PDZ-binding motif (TAZ), leading to their cytoplasmic sequestration and degradation (13,14). When Hippo signaling is inactivated, unphosphorylated YAP and TAZ translocate into the nucleus and interact with transcriptional factors, such as TEA-domain family members (TEADs), mothers against DPP homolog (SMADs), runt related transcription factor (RUNX) and zinc finger E-box binding homeobox 1 (ZEB1), thereby regulating genes involved in cell survival, migration and metabolism (15)(16)(17)(18). Not surprisingly, substantial evidence has shown that dysregulation of the Hippo pathway is involved in various human cancers.…”

Section: Introductionmentioning

confidence: 99%

C12orf59 Promotes Esophageal Squamous Cell Carcinoma Progression via YAP-Mediated Epithelial-Mesenchymal Transition

Lin

et al. 2022

Front. Oncol.

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C12orf59 is a novel gene widely expressed in diverse normal human tissues. Aberrant expression of C12orf59, which is involved in tumor progression, has been reported in a few types of cancer. However, its expression and biological function in esophageal squamous cell carcinoma (ESCC) remain largely unclear. Here, we found that the mRNA and protein levels of C12orf59 were prominently higher in both tumor tissues and most ESCC cell lines. Functionally, C12orf59 overexpression promoted ESCC cell proliferation, migration and invasion, whereas C12orf59 depletion worked oppositely. Mechanistically, C12orf59 exerted its oncogenic function through the induction of epithelial-mesenchymal transition (EMT) of ESCC cells, which relied on Yes-associated protein (YAP) dephosphorylation and nuclear translocation. Constitutively active YAP further facilitated cell migration, invasion and EMT induced by enforced C12orf59 overexpression. On the contrary, increased cell motility and EMT caused by enforced C12orf59 overexpression were dramatically repressed upon YAP inactivation by verteporfin. Thus, we conclude that YAP activation driven by C12orf59 contributes to the malignancy of ESCC through EMT and that targeting drugs for C12orf59 combined with YAP inhibitor may be a potential therapeutic strategy for ESCC.

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The Multiple Interactions of RUNX with the Hippo–YAP Pathway

Cited by 25 publications

References 106 publications

Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds

Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds

Association between Molecular Mechanisms and Tooth Eruption in Children with Obesity

C12orf59 Promotes Esophageal Squamous Cell Carcinoma Progression via YAP-Mediated Epithelial-Mesenchymal Transition

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