The multiple roles of steroids and anabolic steroids and its relations to cardiovasular and musculoskeletal pathology: a brief review

Theodorakidou, Margarita; Nikola, Olti-Alexandra; Lambrou, George I.

doi:10.22540/jrpms-02-022

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…Inflammatory issues such as ophthalmia, yaws and oedema have been managed traditionally [8] . This may be as result of the presence of steroids which are effective as anti-inflammatory agents [25] , they also promote cell growth in particular muscle tissue and bone [26,27] . The presence of terpenoids in B. sapida supports its ethnomedicinal uses in the management of conjunctivitis and other eye-related problems [8] as terpenoids play important roles for vision and are effective for their antioxidative capacity [28] .…”

Section: Discussionmentioning

confidence: 99%

Phytochemical and Phytomineral (macro and trace) compositions of the leaf, stem bark and root of <em>Blighia sapida</em> K.D. Koenig

A¹,

O²

2020

J. Med. Plants Stud.

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Foreign invasions and essential elements inadequacy in the body result in abnormal biological functions of the body, however, medicinal plants trigger desired therapeutic effects through their available phytochemicals and mineral supplementations. Blighia sapida is employed traditionally for the treatment of conjuctivitis, diarrhoea, epilepsy, malaria, internal haemorrhage, ulcer, migraine and as a laxative, among others. This study was designed to analyze the phytochemicals and essential elements present in B.sapida leaf, stem bark and root. The result obtained showed the presence of flavonoids, alkaloids, cardiac glycosides and saponins in all the plant parts but anthraquinones. The highest concentrations of Ca, Mg and K were recorded in the stem bark (6.57±0.16 mg/g), and leaf (1.07±0.03 mg/g and 0.44±0.01 mg/g) respectively while the leaf had the highest concentration of Mn, Fe, P and Cu (0.0116±0.00 mg/g, 0.4747±0.03 mg/g, 0.1142±0.00 mg/g and 0.0011±0.00 mg/g) respectively. This study justifies the ethnopharmacological uses of B. sapida, thus, further studies on the mechanism of action are paramount in order to elucidate the therapeutic roles of all the phytoconstituents.

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Section: Discussionmentioning

confidence: 99%

Phytochemical and Phytomineral (macro and trace) compositions of the leaf, stem bark and root of <em>Blighia sapida</em> K.D. Koenig

A¹,

O²

2020

J. Med. Plants Stud.

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“…Steroids are bio-lipid-based terpenoids that have a structure of four fused carbon skeleton-based rings, which is characterized as the steroid nucleus or sterane. Steroids vary in structure and function because of the different oxidation states of functional groups attached to the rings (Theodorakidou et al, 2018).…”

Section: J Steroidsmentioning

confidence: 99%

Endophytic Fungi: From Symbiosis to Secondary Metabolite Communications or Vice Versa?

et al. 2021

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Endophytic fungi (EF) are a group of fascinating host-associated fungal communities that colonize the intercellular or intracellular spaces of host tissues, providing beneficial effects to their hosts while gaining advantages. In recent decades, accumulated research on endophytic fungi has revealed their biodiversity, wide-ranging ecological distribution, and multidimensional interactions with host plants and other microbiomes in the symbiotic continuum. In this review, we highlight the role of secondary metabolites (SMs) as effectors in these multidimensional interactions, and the biosynthesis of SMs in symbiosis via complex gene expression regulation mechanisms in the symbiotic continuum and via the mimicry or alteration of phytochemical production in host plants. Alternative biological applications of SMs in modern medicine, agriculture, and industry and their major classes are also discussed. This review recapitulates an introduction to the research background, progress, and prospects of endophytic biology, and discusses problems and substantive challenges that need further study.

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“…Leucinostatin has been shown to inhibit the growth of cancer cells [85]. The microbial communities are rich in naturally occurring steroids that are predominantly present in plants and animals [86]. The steroids obtained from fungal endophytes such as ergosterol manifests the additional pharmaceutical properties and natural roles in their producers [87].…”

Section: Overview Of Secondary Metabolitesmentioning

confidence: 99%

Diversity of Endophytic Mycobiota through Metagenomic Approach and Bioprospecting the Phytoconstituent

Thangavel

Mani

Surendrababu

et al. 2022

Advanced Chemicobiology Research

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Endophytic fungi are important organisms that live and thrive in the intercellular or intracellular regions of host tissues of plants without causing immediate or adverse effects on the host plant. Endophytes constitute a large diversity of microbial adaptations that have been developed to survive adverse environments. Plant endophytic fungi play an important role to enhance the uptake and transfer of nutrients from the soil to plants simultaneously influencing the physical and chemical properties of soil. The discovery of fungal endophytes in their natural habitat is quite difficult due to few of its non-sporulating and non-culture-dependent endophytes by the traditional methods. The molecular characterization of isolated fungal endophytes can be carried out by isolation of genomic deoxyribonucleic acid (DNA), polymerase chain reaction (PCR) amplification of internal transcribed spacer (ITS) regions, DNA sequencing and analysis. One of the culture-independent approaches known as ‟metagenomics” is capable of reading the variety of ambient microbes that do not include cultivation from the environmental sample. Several researches on fungal endophytes in plants are in progress and have been under exploitation. Several secondary metabolites with diverse biological activities have been discovered in these fungi, suggesting that they have the ability to create a vast selection of secondary metabolites. In the hunt for new medications such as bioactive properties or innovative drug-like compounds, their variety and specialized habituation make them an attractive subject of research. The review highlights the biology of fungal endophytes, their discovery, isolation and identification by molecular methods.

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The multiple roles of steroids and anabolic steroids and its relations to cardiovasular and musculoskeletal pathology: a brief review

Cited by 4 publications

References 47 publications

Phytochemical and Phytomineral (macro and trace) compositions of the leaf, stem bark and root of <em>Blighia sapida</em> K.D. Koenig

Phytochemical and Phytomineral (macro and trace) compositions of the leaf, stem bark and root of <em>Blighia sapida</em> K.D. Koenig

Endophytic Fungi: From Symbiosis to Secondary Metabolite Communications or Vice Versa?

Diversity of Endophytic Mycobiota through Metagenomic Approach and Bioprospecting the Phytoconstituent

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