The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues

SH3-binding Protein 5 Mediates the Neuroprotective Effect of the Secreted Bioactive Peptide Humanin by Inhibiting c-Jun NH2-terminal Kinase

“…Humanin has other functions aside from inhibition of cell death. Humanin ameliorates cognitive impairment in wild-type mice caused by muscarinic receptor antagonists (15)(16)(17) or by intracerebroventricular injection of amyloid ␤ (A␤) (18 -21), and cognitive impairment of aged familial AD-linked mutant gene-transgenic mice (22)(23)(24).…”

Humanin and the Receptors for Humanin

“…A series of in vitro studies have established that Humanin inhibits neuronal death relevant to AD [2,4,5]. A series of in vivo studies have established that Humanin ameliorates cognitive impairment, caused by the dysfunction of cholinergic neurotransmission, in AD-related mouse models including transgenic mouse models [43][44][45][46][47][48][49][50]. However, because there are no AD animal models with detectable brain atrophy, it remains to be shown whether Humanin inhibits neuronal death in vivo.…”

“…In contrast, stimulation of the Humanin receptor may be an excellent therapeutic strategy to inhibit ADrelevant neuronal death as well as neuronal dysfunction because it is effective against Aβ-dependent and Aβ-independent neuronal death and dysfunction [2,5]. Many Humanin peptide derivatives with stronger activity have been developed and tested on their in vivo activity using several AD mouse models [43][44][45][46][47][48][49][50]. Intranasal administration of the most potent Humanin derivative named Colivelin is very effective against all AD models tested [47,50].…”

Assessment of Potential Long Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances

“…60 An administration of BZ at the dose of 2.0 mg.kg-1 induced disorientation in rodents tested against various maze running activities and passive avoidance tests. 262,263,264 The behavioral alterations were found only when BZ was administered before training; well-trained rats showed no alteration in the test of spatial memory or avoidance. These results indicate that BZ impairs specifically the process of memory acquisition (learning), whereas retrieval of consolidated information (long-term memory) is not affected.…”