Background: In-person caring for coronavirus disease patients amid the outbreak and shortage of medical supplies create burnout and fear of getting infected among healthcare workers. These deem questioning service provision’s efficacy by healthcare workers. This study aims to explore the effect of burnout, stress, depression, and anxiety on the efficacy of health service provision among nurses during the Coronavirus disease outbreak in China, by multiple linear regressionMethods: Our Cross-sectional study utilized three Chinese versions of validated questionnaires; Maslach Burnout Inventory, The General Self-Efficacy Scale, and Depression Anxiety Stress Scales to assess burnout, efficacy, and anxiety among Chinese nurses caring for Coronavirus disease patients during the outbreak. We performed multiple linear regression with burnout, depression, anxiety, and stress scores as independent variables versus general self-efficacy scores as the dependent variable. We used SPSS at a 95% level of significance in the data analysis, and the STROBE tool in the write-up.Results: There was a total of 408 study participants. The majority showed high levels of depersonalization, emotional exhaustion, low levels of personal achievements, and extremely high levels of depression, anxiety, and stress. The general self-efficacy was below the international average. Emotional exhaustion and stress demonstrated a small negative correlation with general self-efficacy. The effect of anxiety and depression on the general self-efficacy was not statistically significant.Conclusions: Coronavirus disease outbreak in China, overwhelmed healthcare facilities creating burnout, anxiety, stress, and depression among nurses working in the hard-hit areas. These may explain an observed lower than average general self-efficacy. However, only stress and emotional exhaustion were associated with reduced general self-efficacy among nurses.