The Muscle-Bone Connection

Brotto, Marco; Isaacson, Janalee; Abreu, Eduardo

doi:10.1007/978-3-319-25976-5_4

Cited by 4 publications

(4 citation statements)

References 176 publications

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“…Now that a skeletal muscle model has been established, one of our future research directions is to incorporate some additional cell‐to‐cell interactions as hypothesized in Brotto et al Going forward, we also intend to use partial differential equations because of the nonhomogeneous nature of of the skeletal muscle regeneration process, particularly with regards to the diffusion of the chemical factor secreted by alternatively activated macrophages to inhibit myogenic apoptosis …”

Section: Discussionmentioning

confidence: 99%

“…In all numerical simulations, recovery is represented by the myofiber regaining cells to within 10% of equilibrium values. Additionally, damages are kept near to the threshold of 40% cell death, which is assumed to be the approximate maximum amount of damage from which muscle may recover to a relatively normal state . All simulations are run for eight weeks to allow the experiments, even those involving multiple damage and recovery cycles, to recover fully.…”

Section: Computer Simulationsmentioning

confidence: 99%

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A mathematical model of skeletal muscle regeneration

Stephenson

Kojouharov

2018

Math Methods in App Sciences

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A novel mathematical model of skeletal muscle regeneration is introduced. It consists of a system of six ordinary differential equations modeling the response of healthy mammalian skeletal muscle tissue to sudden and severe damage. The system is studied analytically to determine its equilibria and their corresponding stability properties. A sensitivity analysis is also conducted to examine the parameters' influence on the system. A set of numerical simulations is performed to simulate various damage and healing scenarios, with and without medical intervention. This model can be used by medical doctors and scientists to forecast the outcomes of medicinal treatments prior to implementation and to guide future laboratory experiments.

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Section: Discussionmentioning

confidence: 99%

Section: Computer Simulationsmentioning

confidence: 99%

A mathematical model of skeletal muscle regeneration

Stephenson

Kojouharov

2018

Math Methods in App Sciences

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“…Obesity and insulin resistance are regarded as chronic inflammation diseases; endurance exercise is effective in improving obesity and insulin resistance by stimulating muscle to secret myokines promoting energy metabolism and alleviating inflammation status (2,5,6). Similarly, brain, heart, bone, and liver also are responded to exercise training via secreted myokines (7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Irisin at the crossroads of inter-organ communications: Challenge and implications

Zhao

2022

Front. Endocrinol.

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The physiological functions of organs are intercommunicated occurring through secreted molecules. That exercise can improve the physiological function of organs or tissues is believed by secreting myokines from muscle to target remote organs. However, the underlying mechanism how exercise regulates the inter-organ communications remains incompletely understood yet. A recently identified myokine–irisin, primarily found in muscle and adipose and subsequently extending to bone, heart, liver and brain, provides a new molecular evidence for the inter-organ communications. It is secreted under the regulation of exercise and mediates the intercommunications between exercise and organs. To best our understanding of the regulatory mechanism, this review discusses the recent evidence involving the potential molecular pathways of the inter-organ communications, and the interactions between signalings and irisin in regulating the impact of exercise on organ functions are also discussed.

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“…Under a societal point of view, as the populations get older, initiatives to reduce the effects of aging on health are particularly important ( Gil-Salcedo et al, 2020 ; Lampek et al, 2021 ). Sarcopenia and osteoporosis, considered twin diseases in the musculoskeletal (MSK) system with high prevalence in older adults, are associated with worse outcomes, including higher morbidity and mortality, following falls ( Huang et al, 2014 ; Brotto et al, 2016 ; Laskou et al, 2021 ). A successful approach to mitigate the effects of these conditions should consider a combination of exercise, particularly resistance training, and good nutritional approach ( Giangregorio et al, 2015 ; Liao et al, 2019 ; Daly et al, 2020 ; Kirk et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Musculoskeletal Biomarkers Response to Exercise in Older Adults

Abreu

Vance²,

Cheng³

et al. 2022

Front. Aging

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Exercise is an essential component of any good health style, being particularly important for older adults to counteract the effects of aging, including sarcopenia and osteoporosis, which can result in lower fall probability. Exercise programs for older adults are especially designed for that population. A rigorous evaluation of those programs is necessary to assure most benefit is achieved. Serum biomarkers of proteins intrinsic to musculoskeletal homeostasis could contribute objectively to the assessment of the benefits of exercise. In this work, in addition to the usual physical fitness and balance tests, ELISA assays quantified the serum levels of six proteins and one polysaccharide important for the homeostasis of muscle (troponin T and alpha-actinin), tendon/ligament (tenomodulin), cartilage (cartilage oligomeric matrix protein and hyaluronan) and bone (osteocalcin and sclerostin), before and after 8 weeks of an exercise program tailored to older adults, Stay Strong Stay Healthy, offered at a Community Center and at an Independent Senior Living facility. Statistical significance was determined by non-parametric tests (Wilcoxon Signed Ranks and Mann-Whitney U). Physical fitness and balance improved as expected along with a significant decrease in sclerostin, pointing to less inhibition of bone deposition. However, when considering each type of dwelling separately, older adults always saw a significant decrease of the isoform of troponin T associated with fast-twitch muscles, suggesting that daily levels of physical activity may also have a role in the benefit of older adults from exercise.

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The Muscle-Bone Connection

Cited by 4 publications

References 176 publications

A mathematical model of skeletal muscle regeneration

A mathematical model of skeletal muscle regeneration

Irisin at the crossroads of inter-organ communications: Challenge and implications

Musculoskeletal Biomarkers Response to Exercise in Older Adults

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