The Mushroom Agaricus Blazei Murill in Combination with Metformin and Gliclazide Improves Insulin Resistance in Type 2 Diabetes: A Randomized, Double-blinded, and Placebo-Controlled Clinical Trial

Abstract

Supplement of ABM extract improves insulin resistance among subjects with type 2 diabetes. The increase in adiponectin concentration after taking AMB extract for 12 weeks might be the mechanism that brings the beneficial effect. Studies with longer periods of follow-up should be conducted in the future.

The Mushroom Agaricus blazei Murill Extract Normalizes Liver Function in Patients with Chronic Hepatitis B

“…5 Rich polysaccharides such as ␤-glucans are found to be the main compounds of ABM. 8,10 ␤-Glucans from ABM have demonstrated antidiabetic activity.…”

“…13 The ABM extract was obtained from dried fungal bodies of ABM, which has been widely taken as a health care product in Taiwan and Japan for years. 5,13 ABM is rich in polysaccharide, which vitalizes production of interferon and interleukin that prevent viruses from entering the tissue. 7 The benefit of ABM on hepatitis B has been demonstrated in an in vivo study.…”

“…Our ABM extract, obtained from Eng Chiao Bio-Technology Co. Ltd., Taiwan, were extracted from dried fungal bodies of ABM according to the preset standard procedures with certificate of analysis given. 5 The subjects were given one capsule containing 500 mg of ABM extract three times each day for 12 months. This capsule was taken 30 minutes after eating.…”

“…It has been reported that ABM has beneficial effects in fighting cancer [1][2][3] and viruses, 4 improving insulin resistance in type 2 diabetes, 5 as well as enhancing production of antibodies by vaccines. 6,7 Chen et al 6 have demonstrated that ABM extract might serve as an adjuvant in improving the efficacy of hepatitis B vaccines in vivo.…”

Dietary Polysaccharides and Immune Modulation

“…For example, A. subrufescens extract (in combination with metformin and gliclazide) improve insulin resistance, potentially by the mechanism that caused an increase in adiponectin concentration after taking the extract for 12 weeks (in vivo) (Hsu et al 2007); G. lucidum extract resulted in hypoglycemic activity (in vivo) (Zhou et al 2005). …”