The Mutagenic Potential of the Human Intestinal Flagellate, Giardia Iamblia P1 Tested on Experimental Mice.

Manna, G. K.; Sadhukhan, A.

doi:10.1508/cytologia.57.241

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“…Human lymphocyte chromosomal preparation. The maximum solubility and concentration give 50% toxicity of culture cell was shown to be 400mg/ml, and doses account according to that by dividing this worm's acetone extract by 10 and treatment doses will be (5,10,20, and 40 mg / ml) of used medium. This protocol was used previously [14] , and modified here according to get series doses.…”

Section: -Various Concentration Of Above Prepared Fasciola Hepatica Acetone Powder Are Used (Sterile Pbs) Againstmentioning

confidence: 99%

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Chromosomal Aberration of Fasciola Hepatica Acetone Powder: In Vitro Study on Human Lymphocytes

Al- Bayati Saad Mohi Haider,

Ali Mohammed Rafeik

2021

Indian Journal of Forensic Medicine & Toxicology

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Fasciola hepatica metazoan trematodes parasite that is living in the liver of their host (sheep, goat and human). It usually cause pathological changes in the parasitized organs. Acetone powder technique is used to prepare partially purified organic material of adult worms. Various concentrations of Fasciola hepatica acetone extract (5 mg/ml, 10 mg /ml , 15mg/ml , 20 mg/ml and 40 mg /ml) are used on human lymphocyte culture for studying some chromosomal aberration. Chromosomal aberrations includes Isogap, Breaks and Dicentrics for chromosomes; Gaps and deletion for chromatids; and mitotic index (MI). This In-vitro study revealed that acetone powder extract of Fasciola hepatica parasites causing various genotoxicity effects in the human lymphocyte cells. These effects are ascending in their increasing in significance differences (P< 0.001) for all treatment against control as concentration of acetone extract is increased.

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Section: -Various Concentration Of Above Prepared Fasciola Hepatica Acetone Powder Are Used (Sterile Pbs) Againstmentioning

confidence: 99%

“…Many parasites exhibited effects on the chromosomes of their host's cell. These effects occur as chromosomal aberrations either In Vitro or In Vivo [10] .…”

Section: Introductionmentioning

confidence: 99%

Chromosomal Aberration of Fasciola Hepatica Acetone Powder: In Vitro Study on Human Lymphocytes

Al- Bayati Saad Mohi Haider,

Ali Mohammed Rafeik

2021

Indian Journal of Forensic Medicine & Toxicology

View full text Add to dashboard Cite

show abstract

The Mutagenic Potential of the Human Intestinal Flagellate, Giardia Iamblia P1 Tested on Experimental Mice.

Cited by 1 publication

References 3 publications

Chromosomal Aberration of Fasciola Hepatica Acetone Powder: In Vitro Study on Human Lymphocytes

Chromosomal Aberration of Fasciola Hepatica Acetone Powder: In Vitro Study on Human Lymphocytes

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