The mutagenicity in procaryotes of herbicides

Grutman, Ghislaine; Schoofs, Louis; Lontie, Jean-Francois; Larebeke, N. Van

doi:10.1007/978-1-4612-5258-0_1

Cited by 7 publications

(6 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mutagencity studies using the Ames assay showed that CIPC had no mutagenic activity (Eisenbeis et al, 1981;and Moriya et al, 1983). No mutagenic effects on prokaryotes were found either (Grutman et al, 1984). The FDA has recommended an upper safety limit of 50 ppm CIPC in fresh whole potatoes.…”

Section: Introductionmentioning

confidence: 96%

Moist and Dry Heat Reduce Isopropyl N‐(3‐Chlorophenyl) Carbamate (CIPC) Residue in Potatoes

Mondy

Wurm

Munshi

1993

Journal of Food Science

View full text Add to dashboard Cite

Moist (boiling and pressure-cooking) and dry heat (baking with and without foil, and microwaving) were compared as to their effect on CIPC retention in potatoes. Tubers were dipped in a 1% emulsion of CIPC for 5 min. prior to processing and stored at 5°C for 0, 1 and 2 mo. All processing methods significantly (~~0.01) reduced CIPC residue in potatoes. Moist heat methods reduced CIPC more than dry heat. Boiling resulted in significantly (~~0.01) greater reduction of CIPC than pressure-cooking while baking without foil resulted in greatest reduction of CIPC followed by microwaving and baking with foil. The peel localized 20 times more CIPC residue than the cortex.

show abstract

Section: Introductionmentioning

confidence: 96%

Moist and Dry Heat Reduce Isopropyl N‐(3‐Chlorophenyl) Carbamate (CIPC) Residue in Potatoes

Mondy

Wurm

Munshi

1993

Journal of Food Science

View full text Add to dashboard Cite

show abstract

“…Despite having been evaluated in several in vitro and mammalian in vivo genetic toxicology assays, the genotoxic potential of diuron is disputable, depending on the experimental protocol, dose levels, and end points evaluated (Grutman et al 1984; Iyer 2002; Liu 2001). A weak mutagenic activity of diuron was reported in a metabolically activated Ames test with Salmonella thyphimurium , but results were negative in a mouse bone marrow micronucleus assay (Seiler 1978).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Diuron (3-[3,4-dichlorophenyl]-1,1-dimethyl urea) in a Two-stage Mouse Skin Carcinogenesis Assay

et al. 2010

View full text Add to dashboard Cite

-1,1-dimethyl urea) is an herbicide with carcinogenic activity in rats and mice, which have developed respectively urothelial and mammary gland tumors in long-term studies. Accordingly, diuron has been categorized as a ''likely human carcinogen'' by the U.S. Environmental Protection Agency. Although the carcinogenesis-initiating activity of diuron has been reported in an early initiation-promotion mouse skin study, its genotoxic potential has been disputed. It is necessary to clarify the mode of action through which it has caused rodent neoplasia and verify its relevance to humans. Herein, two experiments were developed to verify the initiating and promoting potentials of diuron in a twenty-threeand a twenty-one-week-long mouse skin carcinogenesis protocol. In one, dimethylsulfoxide (DMSO) was the solvent for the herbicide; in the other, acetone was the alternative solvent in order to verify whether DMSO had inhibitory influence on a potential cutaneous carcinogenic activity. The adopted schedule for the tumor-promoting agent 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in skin ulcers, which demonstrates the need for careful selection of TPA dose levels and frequency of application in this model. In both studies, diuron did not exert any influence on the skin carcinogenesis process, in contrast with results already reported in the literature.

show abstract

“…Apesar de ter sido avaliado em vários ensaios in vitro e em ensaios in vivo em mamíferos, a genotoxicidade do Diuron é controversa, dependendo do modelo experimental, dose e parâmetros finais estudados (Grutman et al, 1984;Iyer, 2002;Liu, 2001) (Tabela VII -Apêndice). No ensaio de Ames com Salmonella thyphimurium e ativação metabólica, por exemplo, o Diuron apresentou fraca atividade mutagênica, e no teste do micronúcleo em medula óssea os resultados foram negativos (Seiler, 1978).…”

Section: Bioensaios Para Detecção De Cancerígenos Químicosunclassified

“…Despite having been evaluated in several in vitro and mammalian in vivo genetic toxicology assays, the genotoxic potential of diuron is disputable, depending on the experimental protocol, dose levels and endpoints evaluated (Grutman et al, 1984;Iyer, 2002;Liu, 2001). A weak mutagenic activity of diuron was reported in a metabolically activated Ames' test with Salmonella thyphimurium, but results were negative in a mouse bone marrow micronucleus assay (Seiler, 1978).…”

Section: Introductionmentioning

confidence: 99%

Avaliação do potencial cancerígeno do Diuron [3-(3,4-Diclorofenil)-1,1-Dimetiluréia] no modelo de iniciação-promoção cutânea em camundongos swiss

Ferrucio¹

View full text Add to dashboard Cite

Botucatu -SPÀ Ana Rachel, por tantos momentos bons e especiais que passamos juntas, e à Alice, pela segurança de que posso contar com você, mesmo tão distante.Ao meu co-orientador Deilson, pela ajuda na elaboração deste projeto.Aos amigos do TOXICAM: Iza, Mitscheli, Shadia, Marize, Gabrielli, Meri (e Edson), Meire, Tony, João, Alexandre, Paulo, Mara, Ivana e PC, e especialmente à Carla, por tantos conselhos e presentinhos, e à querida "equipe" Ana Paula e Vivi.À Cris, por todas as impressões, telefonemas, scanners, etc...e pelo seu alto astral constante.Aos funcionários do Laboratório de Patologia Molecular: Marquinhos, Selene, Fernando e Cris por todas as vezes que me socorreram.À CAPES e à FAPESP, pelo apoio financeiro, e aos camundongos sacrificados para a realização deste estudo.

show abstract

The mutagenicity in procaryotes of herbicides

Cited by 7 publications

References 47 publications

Moist and Dry Heat Reduce Isopropyl N‐(3‐Chlorophenyl) Carbamate (CIPC) Residue in Potatoes

Moist and Dry Heat Reduce Isopropyl N‐(3‐Chlorophenyl) Carbamate (CIPC) Residue in Potatoes

Evaluation of Diuron (3-[3,4-dichlorophenyl]-1,1-dimethyl urea) in a Two-stage Mouse Skin Carcinogenesis Assay

Avaliação do potencial cancerígeno do Diuron [3-(3,4-Diclorofenil)-1,1-Dimetiluréia] no modelo de iniciação-promoção cutânea em camundongos swiss

Contact Info

Product

Resources

About