The myogenic response in uremic hypertension

Abstract

Increased myogenic tone is not the cause of uremic hypertension.

Altered myogenic constriction and endothelium-derived hyperpolarizing factor-mediated relaxation in small mesenteric arteries of hypertensive subtotally nephrectomized rats

“…In contrast to our hypothesis, in sNX we observed a reduction in the myogenic response of small mesenteric arteries, characterized by the impaired myogenic tone in the pressure range of 100-160 mmHg and altered myogenic index, resulting in a shifted threshold for the development of active myogenic constriction to higher pressures. To our knowledge, the only other study investigating the myogenic response of small resistance arteries in CRF did not find any difference between the myogenic reactivity of small cremaster arteries in sNX and shamoperated rats [22]. Differences in anatomic localization, vascular diameter and function may account for the observed discrepancy with our data.…”

A Theoretical Model for the Myogenic Response Based on the Length–Tension Characteristics of Vascular Smooth Muscle

“…Measured passive length-tension relationships (4,7,9,25,27,28,(30)(31)(32)40,43) are nonlinear, with tension increasing rapidly at higher levels of circumferential stretch. The following exponential form is used to represent the passive tension component:…”

Changes in endothelium-derived hyperpolarizing factor and myogenic response in rats with chronic renal failure and their association with hypertension

“…If the change in threshold response were the contributing factor, a parallel shift in the myogenic response curves would be expected. A decreased myogenic response was also found in the cerebral arteries [16], but not in the skeletal arteries [17], of uremic Wistar-Kyoto rats.…”