The N-(2,4-diarylthiazol-5-yl)benzamidines library creation and the effect of this compounds on cancer cell growth

Abstract

A versatile and efficient protocol for the synthesis of library of N-(2,4-diarylthiazol-5-yl)benzamidines is described. We obtained a library of 25 diversity with different of substituents in four positions in key framework. The synthesized amidine derivatives were evaluated for their in vitro anticancer activity. Analysis of anticancer activity on 60 cancer cell lines showed a decrease of proliferation of Colon Cancer and Leukemia cell lines by more than half and allowed to establish the structure-activity relationship