The n-3 docosapentaenoic acid (DPA): A new player in the n-3 long chain polyunsaturated fatty acid family

Drouin, Gaëtan; Rioux, Vincent; Legrand, Philippe

doi:10.1016/j.biochi.2019.01.022

Cited by 127 publications

(89 citation statements)

References 105 publications

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“…DPA is a precursor of a large class of lipid mediators (special proteins, resolvins, maresins, and isoprostanes) mainly taking part in the elimination of inflammation, with specific effects in contrast to other ω-3 PUFAs. The DPA is beneficial for the cardiovascular system and correlates with risk markers of metabolic diseases, especially with parameters of blood lipids, with platelet aggregation, and with insulin sensitivity [118].…”

Section: Omega-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%

The Short Overview on the Relevance of Fatty Acids for Human Cardiovascular Disorders

et al. 2020

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This review presents existing evidence of the influence of saturated and unsaturated fatty acids on cardiovascular diseases (CVD). Data are discussed regarding the roles of the most relevant fatty acids, such as myristic (C14:0), palmitic (C16:0), stearic (C18:0), palmitoleic (C16:1), oleic (C18:1), linoleic (C18:2), α-linolenic (C18:3, ω-3), γ-linolenic (C18:3, ω-6), arachidonic (C20:4), eicosapentaenoic (C20:5), docosahexaenoic (C22:6), and docosapentaenoic (C22:5) acid. The accumulated knowledge has expanded the understanding of the involvement of fatty acids in metabolic processes, thereby enabling the transition from basic exploratory studies to practical issues of application of these biomolecules to CVD treatment. In the future, these findings are expected to facilitate the interpretation and prognosis of changes in metabolic lipid aberrations in CVD.

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Section: Omega-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%

The Short Overview on the Relevance of Fatty Acids for Human Cardiovascular Disorders

et al. 2020

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“…However, DPA is of current interest both for its ability to increase EPA and DHA tissue status, and for its specific or shared biological effects. Moreover, DPA is the most abundant LC-PUFA in the brain after DHA, and it could be specifically beneficial for the elderly neuroprotection and early-life development [56].…”

Section: Lipid Profile and Adequacymentioning

confidence: 99%

Dietary Intake, Nutritional Adequacy and Food Sources of Total Fat and Fatty Acids, and Relationships with Personal and Family Factors in Spanish Children Aged One to <10 Years: Results of the EsNuPI Study

Madrigal

Soto-Méndez²,

Leis

et al. 2020

Nutrients

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We aimed to determine the usual intake of total fat, fatty acids (FAs), and their main food sources in a representative cohort of the Spanish pediatric population aged 1 to <10 years (n = 707) who consumed all types of milk and an age-matched cohort who consumed adapted milk over the last year (including follow-on formula, toddler’s milk, growing-up milk, and fortified and enriched milks) (n = 741) who were participants in the EsNuPI study (in English, Nutritional Study in the Spanish Pediatric Population). Dietary intake, measured through two 24 h dietary recalls, was compared to the European Food Safety Authority (EFSA) and the Food and Agriculture Organization of the United Nations (UN-FAO) recommendations. Both cohorts showed a high intake of saturated fatty acids (SFAs), according to FAO recommendations, as there are no numerical recommendations for SFAs at EFSA. Also, low intake of essential fatty acids (EFAs; linoleic acid (LA) and α-linolenic acid (ALA)) and long-chain polyunsaturated fatty acids (LC-PUFA) of the n-3 series, mainly docosahexaenoic acid (DHA) were observed according to EFSA and FAO recommendations. The three main sources of total fat and different FAs were milk and dairy products, oils and fats, and meat and meat products. The consumption of adapted milk was one of the main factors associated with better adherence to the nutritional recommendations of total fat, SFAs, EFAs, PUFAs; and resulted as the main factor associated with better adherence to n-3 fatty acids intake recommendations. Knowledge of the dietary intake and food sources of total fat and FAs in children could help in designing and promoting effective and practical age-targeted guidelines to promote the consumption of EFA- and n-3 PUFA-rich foods in this stage of life.

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“…High levels of common polyunsaturated fatty acids, such as EPA and DHA, favor the replacement of arachidonic acid within the phospholipids of the cell membrane [52]. This decreases the binding of arachidonic acid on cyclooxygenase 1, reducing the synthesis of thromboxane A2, which is considered as an element that increases platelet aggregation and vasoconstriction [52,53]. The approach also produces Thromboxane A3, which exerts a low biological effect compared to thromboxane A2.…”

Section: Impact Of ω-3 and ω-6 Pufas In Thrombogenesismentioning

confidence: 99%

Omega 3 versus Omega 6 Polyunsaturated Fatty Acids in Cardio-Metabolic Health

Halim

2020

J Health Care and Research

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Background: Cardiometabolic diseases like type 2 diabetes, metabolic syndrome, heart failure, and other cardiovascular complications are the leading cause of mortality and morbidity across the globe. These conditions are directly attributed to modifiable behaviors such as sedentary activity, poor diet, excessive consumption of alcohol, or smoking. Efforts aimed towards their prevention and management are, therefore, not only essential in the accomplishment of the healthy populations but also for eliminating the associated cost and health burdens. Dietary change is an important approach to the promotion of cardiometabolic health. Omega 3 (C20–22 ω3) polyunsaturated fatty acids have pleiotropic effects on the functioning of cells, control inflammatory factors, and cellular events in vascular endothelial cells and cardiomyocytes. The hypolipemic, anti-arrhythmic, and anti-inflammatory properties of fatty acids offer cardioprotection. Government agencies and national heart associations recommend increased consumption of omega 3 polyunsaturated fatty acids (PUFA) supplements and fish to prevent cardiometabolic diseases. Purpose of the Study: The purpose of this study is to investigate the role played by ω-3 and ω-6 polyunsaturated fatty acids in promoting cardiometabolic health. Methods: The research study searched databases such as MEDLINE®, Embase, PsycINFO, CINAHL® and the Cochrane Library for relevant research studies evaluating the function/benefits of polyunsaturated fatty acids particularly ω-3 and ω-6 polyunsaturated fatty acids in promoting cardiometabolic functions published between 2011 and 2020. A total of 77 research studies were identified and used in the meta-analysis. Results: Results from the meta-analysis indicated that polyunsaturated fatty acids lower the risk for cardiovascular disease by limiting inflammation of blood vessels, reducing thrombosis, increasing levels of high-density lipoproteins, reducing levels of low-density lipoproteins, and reducing risk factors associated with hypertension. Conclusion: Given the benefits of polyunsaturated fatty acids lower the risk for cardiovascular diseases indicted in the meta-analysis. Therefore, human diets must contain the required amounts of PUFA due to the associated benefits.

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The n-3 docosapentaenoic acid (DPA): A new player in the n-3 long chain polyunsaturated fatty acid family

Cited by 127 publications

References 105 publications

The Short Overview on the Relevance of Fatty Acids for Human Cardiovascular Disorders

The Short Overview on the Relevance of Fatty Acids for Human Cardiovascular Disorders

Dietary Intake, Nutritional Adequacy and Food Sources of Total Fat and Fatty Acids, and Relationships with Personal and Family Factors in Spanish Children Aged One to <10 Years: Results of the EsNuPI Study

Omega 3 versus Omega 6 Polyunsaturated Fatty Acids in Cardio-Metabolic Health

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