2020
DOI: 10.1002/2211-5463.12787
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The N‐terminal domains of the paralogous HycE and NuoCD govern assembly of the respective formate hydrogenlyase and NADH dehydrogenase complexes

Abstract: Formate hydrogenlyase (FHL) is the main hydrogen‐producing enzyme complex in enterobacteria. It converts formate to CO2 and H2 via a formate dehydrogenase and a [NiFe]‐hydrogenase. FHL and complex I are evolutionarily related and share a common core architecture. However, complex I catalyses the fundamentally different electron transfer from NADH to quinone and pumps protons. The catalytic FHL subunit, HycE, resembles NuoCD of Escherichia coli complex I; a fusion of NuoC and NuoD present in other organisms. Th… Show more

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Cited by 2 publications
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“…The direct link between NuoC and NuoD in E. coli complex I might help to strengthen this interaction. Indeed, splitting nuoCD into two individual genes led to a loss of complex I activity in the membrane, indicating that the long helix also contributes to the stability of the complex (Skorupa et al, 2020). Furthermore, the loop connecting the two parts of NuoCD interacts with the membrane arm of the complex that might result in strengthening the entire structure.…”
Section: Discussionmentioning
confidence: 99%
“…The direct link between NuoC and NuoD in E. coli complex I might help to strengthen this interaction. Indeed, splitting nuoCD into two individual genes led to a loss of complex I activity in the membrane, indicating that the long helix also contributes to the stability of the complex (Skorupa et al, 2020). Furthermore, the loop connecting the two parts of NuoCD interacts with the membrane arm of the complex that might result in strengthening the entire structure.…”
Section: Discussionmentioning
confidence: 99%