The nano-revolution in the diagnosis and treatment of endometriosis

Volpini, Cristina; Bloise, Nora; Dominoni, Mattia; Barra, Fabio; Vellone, Valerio Gaetano; Minzioni, Paolo; Gardella, Barbara; Ferrero, Simone; Visai, Livia

doi:10.1039/d3nr03527a

Cited by 8 publications

(1 citation statement)

References 159 publications

(223 reference statements)

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“…Endometriosis is an inflammatory gynaecological disease that seriously affects the quality of a woman’s life. The pathogenesis of endometriosis is still unknown, but several leading theories include retrograde menstruation, altered immunity, coelomic metaplasia and metastatic cell spread [ 84 ]. The heterogeneity and differences among the three main classes of endometriosis presentation may suggest different multiple pathogenetic pathways [ 85 ].…”

Section: 3d Culture Models For Endometriosismentioning

confidence: 99%

Growing Role of 3D In Vitro Cell Cultures in the Study of Cellular and Molecular Mechanisms: Short Focus on Breast Cancer, Endometriosis, Liver and Infectious Diseases

Bloise,

Giannaccari,

Guagliano

et al. 2024

Cells

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Over the past decade, the development of three-dimensional (3D) models has increased exponentially, facilitating the unravelling of fundamental and essential cellular mechanisms by which cells communicate with each other, assemble into tissues and organs and respond to biochemical and biophysical stimuli under both physiological and pathological conditions. This section presents a concise overview of the most recent updates on the significant contribution of different types of 3D cell cultures including spheroids, organoids and organ-on-chip and bio-printed tissues in advancing our understanding of cellular and molecular mechanisms. The case studies presented include the 3D cultures of breast cancer (BC), endometriosis, the liver microenvironment and infections. In BC, the establishment of 3D culture models has permitted the visualization of the role of cancer-associated fibroblasts in the delivery of exosomes, as well as the significance of the physical properties of the extracellular matrix in promoting cell proliferation and invasion. This approach has also become a valuable tool in gaining insight into general and specific mechanisms of drug resistance. Given the considerable heterogeneity of endometriosis, 3D models offer a more accurate representation of the in vivo microenvironment, thereby facilitating the identification and translation of novel targeted therapeutic strategies. The advantages provided by 3D models of the hepatic environment, in conjunction with the high throughput characterizing various platforms, have enabled the elucidation of complex molecular mechanisms underlying various threatening hepatic diseases. A limited number of 3D models for gut and skin infections have been developed. However, a more profound comprehension of the spatial and temporal interactions between microbes, the host and their environment may facilitate the advancement of in vitro, ex vivo and in vivo disease models. Additionally, it may pave the way for the development of novel therapeutic approaches in diverse research fields. The interested reader will also find concluding remarks on the challenges and prospects of using 3D cell cultures for discovering cellular and molecular mechanisms in the research areas covered in this review.

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Section: 3d Culture Models For Endometriosismentioning

confidence: 99%

Growing Role of 3D In Vitro Cell Cultures in the Study of Cellular and Molecular Mechanisms: Short Focus on Breast Cancer, Endometriosis, Liver and Infectious Diseases

Bloise,

Giannaccari,

Guagliano

et al. 2024

Cells

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Polymer-drug conjugates: revolutionizing nanotheranostic agents for diagnosis and therapy

Parashar,

Saraogi,

Jain

et al. 2024

Discov Onc

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Nanotheranostics, an amalgamation of therapeutic and diagnostic capabilities at the nanoscale, is revolutionizing personalized medicine. Polymer-drug conjugates (PDCs) stand at the forefront of this arena, offering a multifaceted approach to treat complex diseases such as cancer. This review explores the recent advancements in PDCs, highlighting their design principles, working mechanisms, and the therapeutic applications. We discuss the incorporation of imaging agents into PDCs that allow for real-time monitoring of drug delivery and treatment efficacy. With the aim of improving patient care, the review examines how PDCs enable targeted drug delivery, minimize side effects, and provide valuable diagnostic data, hence enhancing the precision of medical interventions. We also address the challenges facing the clinical translation of PDCs, such as scalability, regulatory hurdles, and cost-effectiveness, providing a comprehensive outlook on the future of nanotheranostics in patient management.

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Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis

Peng,

Zhang,

Yan

et al. 2025

J. Mater. Chem. B

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The nano-revolution in the diagnosis and treatment of endometriosis

Abstract: Endometriosis is a painful gynecological disease with a high prevalence, affecting millions of women worldwide. Innovative, non-invasive treatments, and new patient follow-up strategies are needed to deal with the harmful...

Cited by 8 publications

References 159 publications

Growing Role of 3D In Vitro Cell Cultures in the Study of Cellular and Molecular Mechanisms: Short Focus on Breast Cancer, Endometriosis, Liver and Infectious Diseases

Growing Role of 3D In Vitro Cell Cultures in the Study of Cellular and Molecular Mechanisms: Short Focus on Breast Cancer, Endometriosis, Liver and Infectious Diseases

Polymer-drug conjugates: revolutionizing nanotheranostic agents for diagnosis and therapy

Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis

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