The nanocomposites of modified attapulgite with vitamin E and mannan oligosaccharide regulated the intestinal epithelial barrier and improved intestinal microbiota composition to prevent diarrhea in weaned piglets

Zha, Andong; Tan, Bie; Wang, Jing; Qi, M.; Deng, Yuankun; Liao, Peng; Yin, Yulong

doi:10.1002/jsfa.12642

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…Galactose metabolism has been linked to Megamonas and has been shown to increase feces frequency and consistency 31,32 . Lachnospiraceae 33 is antagonistic to HMOs, Phascolarctobacterium 34 , Roseburia 35 , and Faecalibacterium 36 , and promotes short-chain fatty acid (SCFA) to increase the frequency of bowel movements 37 . The relationship between…”

Section: Discussionmentioning

confidence: 99%

Breast Milk Bacteria: The Key to Regulating Defecation Frequency Changes in Infants

Huang,

Zhang,

Liu

et al. 2024

Preprint

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Breastfeeding can significantly impact the establishment of the infant's intestinal microbiota. In this study, we hypothesized that maternal breast milk bacteria were associated with variations in defecation frequency in infants aged 1 to 6 months who were exclusively breastfed, and we sought to identify potential breast milk microbiota diagnostic markers. 102 exclusively breastfed infants aged at 1 to 6 months were enrolled in the study. Then, we collected their mothers' breast milk as samples for 16S rRNA sequencing evaluation of microbiotas. The results revealed a clear distinction between the three groups regarding microbiota structures and compositions. Changes were observed in the various species and genera, and the breast milk microbiota features Hydrogenobacteria, Serratia, and Allorhizobium-Neorhizobium-Pararhizobium-Rhizobium were confirmed as potential biomarkers for regulating the change in neonate defecation frequency. This study demonstrates a significant correlation between the frequency of defecation in exclusively breastfed infants and the microbiota in their mothers' milk. It was discovered that the human breast milk microbiota may play a significant metabolic role in amino acids and oligosaccharides during its colonization in infants' intestines, which influences their defecation frequency. Our research provides new evidence and hypotheses regarding the association between infant defecation frequency and breast milk microbiome. Trial Registration This trial was registered on 22/12/2023 at www.chictr.org.cn as ChiCTR2300078973.

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Section: Discussionmentioning

confidence: 99%

Breast Milk Bacteria: The Key to Regulating Defecation Frequency Changes in Infants

Huang,

Zhang,

Liu

et al. 2024

Preprint

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The ameliorative roles of dietary mannan oligosaccharides and vitamin E on growth performance, intestinal microbes, and structure, flesh quality, nutrient efficacy and stress resistance of pompano, Trachinotus ovatus

Do-Huu,

Thi Thanh Thuy,

2024

Aquaculture Reports

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Effects of Enteromorpha prolifera polysaccharides on growth performance, intestinal barrier function and cecal microbiota in yellow-feathered broilers under heat stress

Liu,

Wang

et al. 2023

J Animal Sci Biotechnol

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Background Global warming leading to heat stress (HS) is becoming a major challenge for broiler production. This study aimed to explore the protective effects of seaweed (Enteromorpha prolifera) polysaccharides (EPS) on the intestinal barrier function, microbial ecology, and performance of broilers under HS. A total of 144 yellow-feathered broilers (male, 56 days old) with 682.59 ± 7.38 g were randomly assigned to 3 groups: 1) TN (thermal neutral zone, 23.6 ± 1.8 °C), 2) HS (heat stress, 33.2 ± 1.5 °C for 10 h/d), and 3) HSE (HS + 0.1% EPS). Each group contained 6 replicates with 8 broilers per replicate. The study was conducted for 4 weeks; feed intake and body weights were measured at the end of weeks 2 and 4. At the end of the feeding trial, small intestine samples were collected for histomorphology, antioxidant, secretory immunoglobulin A (sIgA) content, apoptosis, gene and protein expression analysis; cecal contents were also collected for microbiota analysis based on 16S rDNA sequencing. Results Dietary EPS promoted the average daily gain (ADG) of broilers during 3–4 weeks of HS (P < 0.05). At the end of HS on broilers, the activity of total superoxide dismutase (T-SOD), glutathione S-transferase (GST), and the content of sIgA in jejunum were improved by EPS supplementation (P < 0.05). Besides, dietary EPS reduced the epithelial cell apoptosis of jejunum and ileum in heat-stressed broilers (P < 0.05). Addition of EPS in HS group broilers' diet upregulated the relative mRNA expression of Occludin, ZO-1, γ-GCLc and IL-10 of the jejunum (P < 0.05), whereas downregulated the relative mRNA expression of NF-κB p65, TNF-α and IL-1β of the jejunum (P < 0.05). Dietary EPS increased the protein expression of Occludin and ZO-1, whereas it reduced the protein expression of NF-κB p65 and MLCK (P < 0.01) and tended to decrease the protein expression of TNF-α (P = 0.094) in heat-stressed broilers. Furthermore, the proportions of Bacteroides and Oscillospira among the three groups were positively associated with jejunal apoptosis and pro-inflammatory cytokine expression (P < 0.05) and negatively correlated with jejunal Occludin level (P < 0.05). However, the proportions of Lactobacillus, Barnesiella, Subdoligranulum, Megasphaera, Collinsella, and Blautia among the three groups were positively related to ADG (P < 0.05). Conclusions EPS can be used as a feed additive in yellow-feathered broilers. It effectively improves growth performance and alleviates HS-induced intestinal injury by relieving inflammatory damage and improving the tight junction proteins expression. These beneficial effects may be related to inhibiting NF-κB/MLCK signaling pathway activation and regulation of cecal microbiota.

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The nanocomposites of modified attapulgite with vitamin E and mannan oligosaccharide regulated the intestinal epithelial barrier and improved intestinal microbiota composition to prevent diarrhea in weaned piglets

Cited by 4 publications

References 40 publications

Breast Milk Bacteria: The Key to Regulating Defecation Frequency Changes in Infants

Breast Milk Bacteria: The Key to Regulating Defecation Frequency Changes in Infants

The ameliorative roles of dietary mannan oligosaccharides and vitamin E on growth performance, intestinal microbes, and structure, flesh quality, nutrient efficacy and stress resistance of pompano, Trachinotus ovatus

Effects of Enteromorpha prolifera polysaccharides on growth performance, intestinal barrier function and cecal microbiota in yellow-feathered broilers under heat stress

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