The Nanoscale Aspects of Chirality in Crystal Growth: Structure and Heterogeneous Equilibria

Advanced prototype using second harmonic generation (SHG) for pre-screening of conglomerates

“…The racemic mixture could have crystallized as a stable conglomerate and the pure enantiomer as a metastable polymorph or solvate (because the enantiomer available has not the same impurity profile as that of the racemic mixture) [6].…”

Solubility of chiral species as function of the enantiomeric excess

“…The macroscopic symmetry of the two enantiomers leads to a representation that is symmetrical with reference of the segment: V‐racemic composition, that is V–(±). This also introduces an extra relationship in the chemical potential, which leads to a modification of the Gibbs phase rule [4,5] n1 and φ1 stand for nonsymmetrical components and nonsymmetrical phases, respectively.…”

“…This also introduces an extra relationship in the chemical potential, which leads to a modification of the Gibbs phase rule. [4,5]…”

Preparative resolution of (±)-trans-1,2-diaminocyclohexane by means of preferential crystallization of its citrate monohydrate

“…3 However, these methods do not always fit with industrial issues such as a high level of enantiomeric purity and a high productivity. An interesting option is to perform the resolution by preferential crystallization (PC) [4][5][6][7] and more interestingly by its auto-seeded variant AS3PC. 8,9 The main advantages of this method are that: (i) no seeding is required; (ii) the stereoselective crystallization is kept under control throughout the process; and (iii) the yield and the filterability of the crops are improved.…”