The nanotechnological approach for nasal delivery of peptide drugs: a comprehensive review

Zuglianello, Carine; Lemos‐Senna, Elenara

doi:10.1080/02652048.2022.2051626

Cited by 4 publications

(1 citation statement)

References 137 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, peptides have a wide range of targeted biological activities [ 14 ]. This allows us to consider them as promising molecules for the development of drugs [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers

Khavinson

Linkova

Kozhevnikova

et al. 2022

IJMS

View full text Add to dashboard Cite

Ultrashort peptides (USPs), consisting of 2–7 amino-acid residues, are a group of signaling molecules that regulate gene expression and protein synthesis under normal conditions in various diseases and ageing. USPs serve as a basis for the development of drugs with a targeted mechanism of action. The purpose of this review is to systematize the available data on USP transport involving POT and LAT transporters in various organs and tissues under normal, pathological and ageing conditions. The carriers of the POT family (PEPT1, PEPT2, PHT1, PHT2) transport predominantly di- and tripeptides into the cell. Methods of molecular modeling and physicochemistry have demonstrated the ability of LAT1 to transfer not only amino acids but also some di- and tripeptides into the cell and out of it. LAT1 and 2 are involved in the regulation of the antioxidant, endocrine, immune and nervous systems’ functions. Analysis of the above data allows us to conclude that, depending on their structure, di- and tripeptides can be transported into the cells of various tissues by POT and LAT transporters. This mechanism is likely to underlie the tissue specificity of peptides, their geroprotective action and effectiveness in the case of neuroimmunoendocrine system disorders.

show abstract

“…Thus, peptides have a wide range of targeted biological activities [ 14 ]. This allows us to consider them as promising molecules for the development of drugs [ 15 ].…”

Section: Introductionmentioning

confidence: 99%