The nanotoxicology revolution

Gebel, Thomas; Marchan, Rosemarie; Hengstler, Jan G.

doi:10.1007/s00204-013-1158-6

Cited by 11 publications

(9 citation statements)

References 70 publications

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“…Silk proteins are created by a diversity of insects and spiders, and materials in a fibrous form of nature, such as spider orb webs and silkworm cocoons . Recently, multifarious studies demonstrated that the general toxicity mechanisms of NPs are related to oxidative stress and inflammation . Therefore, much focus in the design of NPs with escaping properties from immune system that can accommodate drugs to circulate for long times in the blood and to circumvent the physiological barriers encountered on the way to the target sites, and to overcome cell barriers .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the toxicity effects of silk fibroin on human lymphocytes and monocytes

Naserzadeh

Mortazavi

Ashtari

et al. 2018

J Biochem & Molecular Tox

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Silk fibroin nanoparticles (SFNPs) as a natural polymer have been utilized in biomedical applications such as suture, tissue engineering-based scaffolds, and drug delivery carriers. Since there is little data regarding the toxicity effects on different cells and tissues, we aimed to determine the toxicity mechanisms of SFNPs on human lymphocytes and monocytes based on reliable methods. Our results showed that SFNPs (0.5, 1, and 2 mg/mL) induced oxidative stress via increasing reactive oxygen species production, mitochondrial membrane potential (∆Ψ) collapse, which was correlated to cytochrome c release and Adenosine diphosphate (ADP)/Adenosine tri phosphate (ATP) ratio increase as well as lysosomal as another toxicity mechanism, which led to cytosolic release of lysosomal digestive proteases, phosphor lipases, and apoptosis signaling. Taken together, these data suggested that SFNPs toxicity was associated with mutual mitochondrial/lysosomal cross-talk and oxidative stress on human lymphocytes and monocytes with activated apoptosis signaling.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the toxicity effects of silk fibroin on human lymphocytes and monocytes

Naserzadeh

Mortazavi

Ashtari

et al. 2018

J Biochem & Molecular Tox

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“…e l s e v i e r . c o m / l o c a t e / y t a a p correspondingly have received increasing attention for possible toxicity (Ding et al, 2005;Jia et al, 2005;Magrez et al, 2006;Zhu et al, 2006;Pulskamp et al, 2007;Gebel et al, 2013). With the growth of worldwide carbon nanomaterials production (Ball, 2001), there is a likely increase of carbon nanomaterials exposure to humans (Masciangioli and Zhang, 2003;Maynard et al, 2004) including the binding of carbon nanotubes to proteins and DNA in various human organs (Zheng et al, 2003;Karajanagi et al, 2004;Lin et al, 2004;Wang et al, 2004;Singh et al, 2006).…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Exploring possible mechanisms of action for the nanotoxicity and protein binding of decorated nanotubes: interpretation of physicochemical properties from optimal QSAR models

Esposito¹,

Hopfinger

Shao

et al. 2015

Toxicology and Applied Pharmacology

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“…One important way to assess this type of toxicity is based on the presence of biochemical markers of oxidative stress such as reactive oxygen species. 129,130 Other "non-ROS-y" toxicological outcomes have also been documented with nanomaterials. 130,131 Oxidative stress does not directly reveal the presence and physicochemical nature of relevant toxic compounds, such as degradation products and undesired …”

Section: Toxicologymentioning

confidence: 99%

Closing the gap: accelerating the translational process in nanomedicine by proposing standardized characterization techniques

Khorasani¹,

Weaver²,

Salvador-Morales³

2014

IJN

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On the cusp of widespread permeation of nanomedicine, academia, industry, and government have invested substantial financial resources in developing new ways to better treat diseases. Materials have unique physical and chemical properties at the nanoscale compared with their bulk or small-molecule analogs. These unique properties have been greatly advantageous in providing innovative solutions for medical treatments at the bench level. However, nanomedicine research has not yet fully permeated the clinical setting because of several limitations. Among these limitations are the lack of universal standards for characterizing nanomaterials and the limited knowledge that we possess regarding the interactions between nanomaterials and biological entities such as proteins. In this review, we report on recent developments in the characterization of nanomaterials as well as the newest information about the interactions between nanomaterials and proteins in the human body. We propose a standard set of techniques for universal characterization of nanomaterials. We also address relevant regulatory issues involved in the translational process for the development of drug molecules and drug delivery systems. Adherence and refinement of a universal standard in nanomaterial characterization as well as the acquisition of a deeper understanding of nanomaterials and proteins will likely accelerate the use of nanomedicine in common practice to a great extent.

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The nanotoxicology revolution

Cited by 11 publications

References 70 publications

Evaluation of the toxicity effects of silk fibroin on human lymphocytes and monocytes

Evaluation of the toxicity effects of silk fibroin on human lymphocytes and monocytes

Exploring possible mechanisms of action for the nanotoxicity and protein binding of decorated nanotubes: interpretation of physicochemical properties from optimal QSAR models

Closing the gap: accelerating the translational process in nanomedicine by proposing standardized characterization techniques

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