The nasal distribution of metered does inhalers

Newman, S P; Morén, Folke; Clarke, S W

doi:10.1017/s0022215100101380

Cited by 64 publications

(40 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Variations in technique apparently make little difference to the site of deposition in the nose. However good the technique, some 80% of the dose of a nasal aerosol is deposited in the anterior one-third of the nose and penetration is negligible beyond the narrow point known as the "nasal valve" (Newman et al 1987). In any case, site of placement by micropipette seems to make little difference to nicotine absorption (Johansson et at.…”

Section: Discussionmentioning

confidence: 99%

Nasal nicotine spray: a rapid nicotine delivery system

Sutherland¹,

Russell²,

Stapleton³

et al. 1992

Psychopharmacology

View full text Add to dashboard Cite

Plasma nicotine concentrations following administration by two types of nasal nicotine spray were compared in ten subjects. Absorption was particularly rapid during the first 2.5 min, the average rise in blood nicotine concentrations during this time being 8.6 ng/ml for the two products, followed by a small further rise to an average peak increase of 10.5 ng/ml 5 min after the dose of 2 mg nicotine base (mean 27.8 micrograms/kg). Despite a four-fold Cmax variation between subjects, the levels of individual subjects were fairly consistent across the two products. There were no significant differences between the two products in blood nicotine concentrations or cardiovascular responses, and the correlation between the AUCs from the two products was 0.68 (P = 0.01). Eight subjects reported subjective feelings of light-headedness or slight dizziness, which are not typical after slower absorption from nicotine gum or skin patches. Blood nicotine levels within the smoking range were soon built up with repeated doses, even in the subject with the least efficient nasal absorption. In a second study of ad libitum use under clinical conditions both products appeared sufficiently acceptable for therapeutic use as an aid to smoking cessation. There was no tendency to escalate to excessive use over 4 weeks, and blood nicotine concentrations in nine subjects averaged only 44% of their prior smoking levels. Only one subject had levels equivalent to prior smoking and possible reasons why this was not more common are discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Nasal nicotine spray: a rapid nicotine delivery system

Sutherland¹,

Russell²,

Stapleton³

et al. 1992

Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Nasal aerosols (Newman et al 1987b ) that utilize propellants to generate the spray have been shown to have smaller droplets compared to conventional nasal sprays. However, the deposition pattern is even more localized because of the exit velocity of the plume.…”

Section: Nasal Physiologymentioning

confidence: 99%

Considerations for the Development of Nasal Dosage Forms

Ehrick¹,

Shah²,

Shaw³

et al. 2013

AAPS Advances in the Pharmaceutical Sciences Series

View full text Add to dashboard Cite

The anatomy and physiology of the nasal cavity provide unique advantages for accessing targets for local, systemic, and potentially central nervous system drug delivery. This chapter discusses these advantages and the challenges that must be overcome to reach these targets. The chapter then comprehensively reviews nasal dosage forms, analytical testing, and regulatory requirements in the context of existing nasal spray products. Since nasal sprays are moving towards being preservativefree, the chapter covers specialized methods of achieving a sterile product, namely, formulation strategies, manufacturing strategies, and the device landscape that support this upcoming platform. Finally, the chapter reviews various pathways for regulatory approval around the world, for brand and generic, with particular emphasis on the growing acceptance of in vitro data for locally acting nasal spray products.

show abstract

“…And the total surface area of the nasal cavity is around 150 cm 2 [10] . The proportion of the ciliated epithelium that nasal spray reaches is able to be readily assessed by observing the proportion of nasal spray transported by mucociliary flow [11] . Berridge et al introduced a technique which utilizes positron emission tomography (PET) to measure the radioactivity of administered isotopes [12] .…”

Section: Discussionmentioning

confidence: 99%

Septoplasty and decongestant improve distribution of nasal spray

Fan

Feng

et al. 2011

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

View full text Add to dashboard Cite

This study prospectively examined the intranasal distribution of nasal spray after nasal septal correction and decongestant administration. A cohort of 20 patients was assessed for the distribution of nasal spray before and after nasal septum surgery. Sprays were dyed and administered one puff per nostril when patients hold their head up in an upright position. Before and after decongestant administration, the intranasal distribution was semi-quantitatively determined by nasal endoscopy. The results showed that the dyed drug was preferentially sprayed onto the nasal vestibule, the head of the inferior turbinate, the anterior part of septum and nasal floor. As far as the anterior-inferior segment of the nasal cavity was concerned, the distribution was found to be influenced neither by the decongestant nor by the surgery (P>0.05). However, both the decongestant and surgery expanded the distribution to the anatomical structures in the superior and posterior nasal cavity such as olfactory fissure, middle turbinate head and middle nasal meatus. No distribution was observed in the sphenoethmoidal recess, posterior septum, tail of inferior turbinate and nasopharynx. It was concluded that nasal septum surgery and decongestant administration significantly improves nasal spray distribution in the nasal cavity.

show abstract

The nasal distribution of metered does inhalers

Cited by 64 publications

References 7 publications

Nasal nicotine spray: a rapid nicotine delivery system

Nasal nicotine spray: a rapid nicotine delivery system

Considerations for the Development of Nasal Dosage Forms

Septoplasty and decongestant improve distribution of nasal spray

Contact Info

Product

Resources

About