The Nasal Fossa of Mouse and Dwarf Lemurs (Primates, Cheirogaleidae)

Smith, Timothy D.; Rossie, James B.

doi:10.1002/ar.20752

Cited by 11 publications

(43 citation statements)

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“…Thin scrolls of bone (turbinals) that both elaborate surface area (SA) and subdivide nasal space are used as morphological proxies for olfactory and respiratory physiology. The present study offers additional details on the nasal fossa of the adult mouse lemur (Microcebus murinus), previously described by Smith and Rossie (Smith and Rossie [2008]; Anatomical Record 291:895-915). Additional, intervening histological sections of the specimen were used to map and quantify the distribution of olfactory and nonolfactory mucosa on the smaller turbinal of the frontal recess (FR; frontoturbinal) and those that occur between ethmoturbinals (ETs; interturbinals).…”

Section: Introductionmentioning

confidence: 79%

“…One 4-year-old male mouse lemur was used to obtain measurements of SA for internal nasal structures. Smith and Rossie (2008) previously reported total internal nasal SA for this specimen, and SA for selected turbinals. In this study, additional sections were mounted to obtain more detailed estimates of SA for internal nasal structures and spaces.…”

Section: Methodsmentioning

confidence: 90%

“…In this study, additional sections were mounted to obtain more detailed estimates of SA for internal nasal structures and spaces. The nasoturbinal (NT) and interturbinals, which were not previously measured as separate structures (but were included in total SA by Smith and Rossie, 2008), were then studied. Additional sections were also examined near end points of all other internal nasal structures and spaces.…”

Section: Methodsmentioning

confidence: 99%

“…Methodological specifics concerning identification of olfactory and nonolfactory epithelium were described previously (Smith and Rossie, 2008). Briefly, features such as Bowman's glands, multiple rows of round nuclei of olfactory receptor neurons, and olfactory nerves were used to identify olfactory mucosa.…”

Section: Quantification Of Olfactory and Nonolfactory Surface Area Anmentioning

confidence: 99%

“…In a recent article (Smith and Rossie, 2008), the development of the nasal fossa in cheirogaleid primates (mouse and dwarf lemurs) was described, including estimates of internal nasal mucosal surface areas (SAs) in a perinatal and adult mouse lemur (Microcebus murinus). Generally, this study revealed that snout length is a misleading proxy for olfactory capabilities in primates, because the anterior portion of the snout disproportionately bears nonolfactory mucosa, as in many other mammals (Negus, 1958).…”

mentioning

confidence: 99%

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Distribution of Olfactory and Nonolfactory Surface Area in the Nasal Fossa of Microcebus murinus: Implications for Microcomputed Tomography and Airflow Studies

Smith

Eiting

Rossie

2011

The Anatomical Record

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The nasal fossa of most mammals exemplifies extreme skeletal complexity. Thin scrolls of bone (turbinals) that both elaborate surface area (SA) and subdivide nasal space are used as morphological proxies for olfactory and respiratory physiology. The present study offers additional details on the nasal fossa of the adult mouse lemur (Microcebus murinus), previously described by Smith and Rossie (Smith and Rossie [2008]; Anatomical Record 291:895-915). Additional, intervening histological sections of the specimen were used to map and quantify the distribution of olfactory and nonolfactory mucosa on the smaller turbinal of the frontal recess (FR; frontoturbinal) and those that occur between ethmoturbinals (ETs; interturbinals). A second adult Microcebus specimen, available as a dried skull, was scanned using microcomputed tomography (microCT) and reconstructed to infer the position of these turbinals within the nasal airway. Overall, turbinal bones comprise more than half of internal nasal SA. All ETs combined comprise about 30% of total nasal fossa SA, and contribute nearly half of all olfactory SA. Of these, the nasoturbinal (NT) is most completely covered with olfactory mucosa, whereas ET I is least covered with olfactory mucosa. The FR contributes significantly to total olfactory SA (ca. 20%). This recess and the single frontoturbinal within it lie in a more lateral pathway of airflow compared with interturbinals, which lie in more central zone just anterior to the olfactory recess of Microcebus. Variations in the turbinals and recesses that complicate central and paranasal in primates should be investigated further in light of zone-specific distributions of olfactory receptors (ORs) that differ between these regions in rodents. Anat Rec, 294:1217Rec, 294: -1225

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Section: Introductionmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Quantification Of Olfactory and Nonolfactory Surface Area Anmentioning

confidence: 99%

mentioning

confidence: 99%

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Distribution of Olfactory and Nonolfactory Surface Area in the Nasal Fossa of Microcebus murinus: Implications for Microcomputed Tomography and Airflow Studies

Smith

Eiting

Rossie

2011

The Anatomical Record

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The Anatomical Record Inside the Head: A History of Reporting Findings on the Skull, Paranasal Sinuses, and Nose

Laitman

Albertine²

2008

The Anatomical Record

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Anatomical Details of the Rabbit Nasal Passages and Their Implications in Breathing, Air Conditioning, and Olfaction

April

Kim

et al. 2016

The Anatomical Record

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The rabbit is commonly used as a laboratory animal for inhalation toxicology tests and detail knowledge of the rabbit airway morphometry is needed for outcome analysis or theoretical modeling. The objective of this study is to quantify the morphometric dimension of the nasal airway of a New Zealand white rabbit and to relate the morphology and functions through analytical and computational methods. Images of high-resolution MRI scans of the rabbit were processed to measure the axial distribution of the cross-sectional areas, perimeter, and complexity level. The lateral recess, which has functions other than respiration or olfaction, was isolated from the nasal airway and its dimension was quantified separately. A low Reynolds number turbulence model was implemented to simulate the airflow, heat transfer, vapor transport, and wall shear stress. Results of this study provide detailed morphological information of the rabbit that can be used in the studies of olfaction, inhalation toxicology, drug delivery, and physiology-based pharmacokinetics modeling. For the first time, we reported a spiral nasal vestibule that splits into three paths leading to the dorsal meatus, maxilloturbinate, and ventral meatus, respectively. Both non-dimensional functional analysis and CFD simulations suggested that the airflow in the rabbit nose is laminar and the unsteady effect is only significantly during sniffing. Due to the large surface-to-volume ratio, the maxilloturbinate is highly effective in warming and moistening the inhaled air to body conditions. The unique anatomical structure and respiratory airflow pattern may have important implications for designing new odorant detectors or electronic noses.

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The Nasal Fossa of Mouse and Dwarf Lemurs (Primates, Cheirogaleidae)

Abstract: Ventral view of a computer‐generated, 3D reconstruction of the nasal capsule in a 16 mm CRL Microcebus murinus. The position of the eyes is lateral to the nasal capsule. See Smith et al., Anatomical Record 291:895–915.

Cited by 11 publications

References 0 publications

Distribution of Olfactory and Nonolfactory Surface Area in the Nasal Fossa of Microcebus murinus: Implications for Microcomputed Tomography and Airflow Studies

Distribution of Olfactory and Nonolfactory Surface Area in the Nasal Fossa of Microcebus murinus: Implications for Microcomputed Tomography and Airflow Studies

The Anatomical Record Inside the Head: A History of Reporting Findings on the Skull, Paranasal Sinuses, and Nose

Anatomical Details of the Rabbit Nasal Passages and Their Implications in Breathing, Air Conditioning, and Olfaction

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