The National Conference Committee

Ferry, Frederick C.

doi:10.1126/science.37.964.933

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2017

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“…None of the animals showed any signs of systemic adverse events or impairment over the course of the study. Weight gain during the study was in the normal range [27,28]. A total of 11 of 32 injected eyes developed localized posterior capsular opacity (cataract) along the injection needle direction (PEA group = 4/12, PLGA group = 5/12, PEA+DEX group = 2/8, Control group = N/A).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of polyesteramide (PEA) and polyester (PLGA) microspheres as intravitreal drug delivery systems in albino rats

et al. 2017

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Although morphological changes such as mild glial activation and material remnants were observed histologically 1 month and 3 months after injection in all injected groups, minor cell damage was noted only in the PLGA group at 3 months after injection. No evidence of functional abnormality relative to untreated eyes could be detected by ERG 3 months after injection in all groups. Changes observed in in vivo imaging such as OCT and FAF disappeared after 3 months in almost all cases.

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Section: Resultsmentioning

confidence: 99%