2017
DOI: 10.7324/japs.2017.70506
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The natural anti-tubercular agents: In silico study of physicochemical, pharmacokinetic and toxicological properties

Abstract: The purpose of the present study is to explore the physicochemical, pharmacokinetic and toxicological properties and to correlate the calculated physicochemical properties with the absorption and distribution profile of seven natural anti-tubercular agents such as 6a,7-dehydro-N-formylnornantenine (DNF), Aristololactam (AL), Isoambreinolide (IA), Andrographolide (AGD), 8,8'-Biplumbagin (BPG), Plumericin (PC) and Tiliacorine (TC). The physicochemical properties such as intrinsic solubility (solubility of unioni… Show more

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“…Membrane transporters of substances in either an intracellular or extracellular route are known as P-glycoproteina (P-gp) (Levin, 2012). Consequently, only the efficacy of all compounds may be blocked at various target sites (Khan et al, 2017). One of the top priorities during the drug discovery process is the prediction of the metabolism of lead compounds (Wang et al, 2015).…”
Section: Pharmacokinetic Propertiesmentioning
confidence: 99%
“…Membrane transporters of substances in either an intracellular or extracellular route are known as P-glycoproteina (P-gp) (Levin, 2012). Consequently, only the efficacy of all compounds may be blocked at various target sites (Khan et al, 2017). One of the top priorities during the drug discovery process is the prediction of the metabolism of lead compounds (Wang et al, 2015).…”
Section: Pharmacokinetic Propertiesmentioning
confidence: 99%