A retrospective study of 150 consecutive Negro patients with histologically confirmed gastric carcinoma seen at Howard University Hospital, Washington, DC, between 1960–1972 is described. The age and sex distribution of cases, histologic appearance of carcinoma, and operability rate were similar to series of predominantly Caucasian patients. However, 12 patients had coexistent peptic ulcer disease, 2 (1.33%) had an active duodenal ulcer; no patient had a history of pernicious anemia. In contrast to previous reports on blood groups and stomach cancer, blood group data revealed an excess of blood group B and a deficiency of blood group O, in Negro cancer patients (p > 0.01). According to the TNM staging system, 73% of Negro patients, and only 53% of control patients (a 79% Caucasian series) had Stage IV carcinoma (p > 0.005). Moreover, for any given stage of the disease, Negro patients had a shorter survival than Caucasians.