The natural history of cow's milk allergy in north-eastern Poland

Kaczmarski, Maciej; Wasilewska, Jolanta; Cudowska, Beata; Semeniuk, Janusz; Klukowski, Mark; Matuszewska, E

doi:10.2478/v10039-012-0053-3

Cited by 18 publications

(22 citation statements)

References 37 publications

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“…These have been most studied in association with egg, milk, and peanut allergy, the most common childhood food allergens. Factors associated with the timing of resolution of allergy to these foods include severity of symptoms on ingestion 31-35 , skin prick test (SPT) size 31, 33, 36, 37 , age at diagnosis 31, 38 , comorbid allergic disease 39-42 and severity 31, 33 , food specific IgE levels 21, 31-33, 36, 39, 43-45 , rate of change of food specific IgE levels 38 or SPT sizes 36 , IgE epitope specificity 46 , IgE/ IgG 4 ratio 47 , and specific IgA and IgA2 levels 48 . While these were identified in children with egg, milk, or peanut allergy, it is likely that these principles are generalizable to other food allergens, and this warrants further study.…”

Section: Natural Coursementioning

confidence: 99%

Food Allergy

Savage¹,

Johns²

2015

Immunology and Allergy Clinics of North America

248

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Synopsis The prevalence of food allergy is rising for unclear reasons, with prevalence estimates in the developed world approaching 10%. Knowledge regarding the natural course of food allergies is important because it can aid the clinician in diagnosing food allergies and in determining when to consider evaluation for food allergy resolution. Many food allergies with onset in early childhood are outgrown later in childhood, although a minority of food allergy is persistent into adolescence and even adulthood. More research is needed to improve food allergy diagnosis, treatment, and prevention.

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Section: Natural Coursementioning

confidence: 99%

Food Allergy

Savage¹,

Johns²

2015

Immunology and Allergy Clinics of North America

248

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“…The number of food allergy students decreased in the order of Non-Diagnosis group (3.55%) > Single Diagnosis group (0.69%) > Double Diagnosis group (0.40%). Many previous studies have reported that children acquire tolerance as they develop, and although there is a discrepancy depending on the food allergen, 30–80% of food allergies heal naturally [ 26 , 27 , 28 , 29 ]. The present study revealed that when there are more opportunities to seek medical examination and a doctor’s diagnosis at both the beginning and during accommodations such as the Double Diagnosis group, it can be presumed to result in students visiting medical institutions and recognizing their acquired tolerance or excessively worried guardians being deterred from requesting food allergy accommodations for their child, ultimately omitting unconfirmed food allergy student and reducing the percentage of true food allergy students.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the average number of food allergens for food allergy students increased in the order of Non-Diagnosis group (1.52 foods) < Single Diagnosis group (2.22 foods) < Double Diagnosis group (2.42 foods). It is often the case with food allergies that tolerance is acquired as one develops, decreasing the number of foods allergens [ 26 , 27 , 28 , 29 ]. Therefore, although the number of food allergens were expected to decrease with an increase in doctor’s diagnosis, the results went against this expectation.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between the Status of Unnecessary Accommodations Being Made to Unconfirmed Food Allergy Students and the Presence or Absence of a Doctor’s Diagnosis

et al. 2015

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The present study investigated the current state of unnecessary children food allergy accommodation and the medical efforts to confirm the existence of food allergies in school lunch service kitchens in Okinawa, Japan, including kitchens accommodating food allergy students by requiring medical documentation at the start and during provisions being made (Double Diagnosis), requiring medical documentation at the start only (Single Diagnosis), and with no medical documentation (Non-Diagnosis). Unnecessary accommodations are being made to unconfirmed food allergy students, wherein the more medical consultation was required, the lower the food allergy incident rate was and the more food allergens were diagnosed (Non-Diagnosis > Single Diagnosis > Double Diagnosis). This study suggests the possibility that unconfirmed food allergy students may be receiving unnecessary food allergy accommodations per school lunches, and the number of unnecessary food allergy provisions being made could be reduced by requiring medical documentation at the start and during these provisions.

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“…Whilst it is established that there are certain risk factors for the development of food allergy, for example eczema and family history, it is not yet clear whether the presence or absence of these risk factors are associated with the persistence or resolution of food allergy. Although several studies have examined these, results are largely inconsistent [ 22 , 41 , 49 , 54 , 59 , 60 ]. However, if these factors are demonstrated to offer predictive value to the course of food allergy, the sensitivity and specificity of SPT and sIgE may be further improved by stratifying upon these factors.…”

Section: Summary and Future Directionsmentioning

confidence: 99%

The Natural History of IgE-Mediated Food Allergy: Can Skin Prick Tests and Serum-Specific IgE Predict the Resolution of Food Allergy?

Peters

Gurrin

Dharmage

et al. 2013

IJERPH

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IgE-mediated food allergy is a transient condition for some children, however there are few indices to predict when and in whom food allergy will resolve. Skin prick test (SPT) and serum-specific IgE levels (sIgE) are usually monitored in the management of food allergy and are used to predict the development of tolerance or persistence of food allergy. The aim of this article is to review the published literature that investigated the predictive value of SPT and sIgE in development of tolerance in children with a previous diagnosis of peanut, egg and milk allergy. A systematic search identified twenty-six studies, of which most reported SPT or sIgE thresholds which predicted persistent or resolved allergy. However, results were inconsistent between studies. Previous research was hampered by several limitations including the absence of gold standard test to diagnose food allergy or tolerance, biased samples in retrospective audits and lack of systematic protocols for triggering re-challenges. There is a need for population-based, prospective studies that use the gold standard oral food challenge (OFC) to diagnose food allergy at baseline and follow-up to develop SPT and sIgE thresholds that predict the course of food allergy.

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The natural history of cow's milk allergy in north-eastern Poland

Cited by 18 publications

References 37 publications

Food Allergy

Food Allergy

The Relationship Between the Status of Unnecessary Accommodations Being Made to Unconfirmed Food Allergy Students and the Presence or Absence of a Doctor’s Diagnosis

The Natural History of IgE-Mediated Food Allergy: Can Skin Prick Tests and Serum-Specific IgE Predict the Resolution of Food Allergy?

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