The natural history of halo nevi: A retrospective case series

Aouthmany, Mouhammad; Weinstein, Mara; Zirwas, Matthew J.; Brodell, Robert T.

doi:10.1016/j.jaad.2011.11.937

Cited by 65 publications

(41 citation statements)

References 28 publications

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“…In some cases, the hypopigmented halo anticipates the total or partial regression of the melanocytic lesion, while in others it remains stable or eventually undergoes repigmentation. [1] HN is not uncommon, being more frequent around acquired melanocytic nevus. [2] Up to 26% of patients with HN have vitiligo, [3] but in very few instances is there an association of HN around CMN and vitiligo.…”

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confidence: 99%

“…The occurrence of halo CMN is a well-known phenomenon, as is its association with vitiligo, [1][2][3][4][5] but halo repigmentation in congenital melanocytic lesions is exceptional. [4] We have found only two more cases in the literature: A 2-year-old boy with a CMN on the arm who experienced total regression of the CMN and partial repigmentation [5] and another case included in a series of cases of halo CMN and vitiligo in which some repigmentation was observed at the periphery.…”

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confidence: 99%

“…[4] We have found only two more cases in the literature: A 2-year-old boy with a CMN on the arm who experienced total regression of the CMN and partial repigmentation [5] and another case included in a series of cases of halo CMN and vitiligo in which some repigmentation was observed at the periphery. [4] Additionally, in a series of 52 patients with HN in which no differentiation between acquired and congenital lesions was made, the authors state that partial or complete repigmentation of the HN was observed after an average follow-up of 11.8 and 7.8 years, respectively, [1] so it is possible that repigmentation may occur later in life and regression of HN in all CMN is a question of time. Management of CMN with halo does not differ from cases without peripheral depigmentation, and periodic follow-up is recommended unless worrisome changes occur.…”

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confidence: 99%

“…Both UV-A and UV-B induce tanning. [1] Clothes provide protection from the harmful effects of ultraviolet rays especially tanning. The measurement of the protective effect of clothes is measured by fabric ultraviolet protection (UPF).…”

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Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy

Concha-Garzón

Hernández‐Martín

Faura-Berruga

et al. 2014

Indian J Dermatol Venereol Leprol

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Figure 1: (a) Halo CMN on the inner aspect of the right knee when the patient was 8 years old. (b) Follow-up at the age of 10 years. Partial regression of the CMN is observed, as well as patchy areas of repigmentation. (c and d) Substantial repigmentation both halo CMN and vitiligo when the patient was 13 years old d c b a [Downloaded free from http://www.ijdvl.com on Tuesday, January 21, 2014, IP: 202.164.45.14] || Click here to download free Android application for this journal Letters to the Editor

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Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy

Concha-Garzón

Hernández‐Martín

Faura-Berruga

et al. 2014

Indian J Dermatol Venereol Leprol

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“…[3] The present study was taken up to explore the morphologic evidence of a common stem using melanocyteangiogenic interactions in melanocytic lesions as a model, the melanocytes being neural crest derivatives. [4,5] The appearance of a halo nevus and/or vitiligo [6][7][8] can herald a complete regression of melanomas in occasional cases. In a random series of nodular melanomas, the appearance of a halo nevus (HN) along with vitiligo was associated with a complete regression of the co-existing melanoma with extensive metastasis.…”

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Melanocyte-endothelial melanomas: Plasticity and transdifferentiation in melanomas

Iyengar¹

2016

JST

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Melanomas with extensive metastasis can rarely regress on the appearance of a halo nevus (HN). This study explores the possible factors involved. The component melanocytes of HN, flatten, depigment and line vascular spaces to replace and result in the involution of the nevus. This simulates vasculogenesis in amelanotic melanomas, malignant melanocytes differentiating into endothelial cells. The reverse is seen in pigmented tumors. Nestin positive endothelial cells lining angiogenic tubes, enter the tumor margins, show glial differentiation and form transient tumor vascular complexes (TVC) with stepwise neural differentiation and pigment laden cells, suggesting transdifferentiation of endothelial cells to melanocytes. During development, a range of molecular tools are used by blood vessels as well as nerves, including ephrins/Eph, NP-I and Notch signalling. This is vindicated by morphologic evidence of melanocyte/endothelial transdifferentiation as shown in this study. These observations, suggest a common multipotent stem cell, differentiating into vascular and melanocyte/neural stem cell depending on the surrounding microenviroment. Concurrent tumor regression may involve a rapid transdifferentiation triggered by a molecular switch or shut down of the common stem cell and/or presence of circulating antibodies to melanomas released on the appearance of HN.

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Benign Melanocytic Proliferations and Melanocytic Naevi

Stefanaki

Antoniou

Stratigos

2016

Rook's Textbook of Dermatology, Ninth Edition

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Benign cutaneous melanocytic proliferations are the most common neoplasms occurring in humans. Although benign in nature, they are often problematic for the patient due to aesthetic concerns or their association with other medical conditions. For dermatologists, melanocytic lesions are generally considered risk factors, precursors or simulants of melanoma, posing significant diagnostic and management issues in clinical practice. This chapter describes the spectrum of benign melanocytic lesions, their divergent clinical varieties and underlying pathogenetic pathways, their histological features, their association with other diseases – particularly melanoma – and their current principles of treatment.

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The natural history of halo nevi: A retrospective case series

Cited by 65 publications

References 28 publications

Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy

Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy

Melanocyte-endothelial melanomas: Plasticity and transdifferentiation in melanomas

Benign Melanocytic Proliferations and Melanocytic Naevi

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