The natural history of untreated skull base meningiomas

Bindal, Rajesh K.; Goodman, Julius M.; Kawasaki, Aki; Purvin, Valerie A.; Kuzma, Benjamin B.

doi:10.1016/s0090-3019(02)00995-3

Cited by 80 publications

(43 citation statements)

References 13 publications

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“…According to their data, the time for the most change in size was between 5 and 10 years. [1] Conclusion:-Our meta-analysis supported that factors significantly favor tumor growth are younger patients age, larger initial tumor size, T2 hyper intensity, peri-tumoral edema. While only intra-tumoral calcification significantly favor slow or even no tumor grows.…”

Section: Growth Rates:-mentioning

confidence: 58%

“…Twelve studies reported patients that ultimately underwent surgery [1,4,5,6,7,8,13,14,16,17,21,23]. Among patients with growing tumors, 27.8% underwent surgery, either open, radiosurgery, or both.…”

Section: Growth Rates:-mentioning

confidence: 99%

“…Published reports are often limited by a retrospective study design, small sample size, and short follow-up period. [1][2][3][4][5][6][7][8][9][10][11][12][13][14]16,17,19,[21][22][23] A systematic review and meta-analysis of the studies currently available allows for a better understanding of the natural course of asymptomatic meningiomas, a platform for more research, and a foundation on which a standardized guideline for following these tumors may be built.…”

mentioning

confidence: 99%

See 2 more Smart Citations

The Natural Course of Incidental Intracranial Meningiomas: Systematic Review and Meta-Analysis.

Eltantawy¹,

Nabeel²,

Bayomy³

2018

IJAR

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Section: Growth Rates:-mentioning

confidence: 58%

Section: Growth Rates:-mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

The Natural Course of Incidental Intracranial Meningiomas: Systematic Review and Meta-Analysis.

Eltantawy¹,

Nabeel²,

Bayomy³

2018

IJAR

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“…Meningiomas represent 13-26% of all intracranial masses with a female to male ratio of 2:1 and most often occur beyond the 5th decade. [11][12][13][14] On CT, meningiomas may show associated hyperostosis as a supportive finding and approximately 75% appear hyperattenuating to brain. Classic MRI appearances are those of a T1 and T2 isointense lesion with avid contrast enhancement and an enhancing dural "tail", but this is not a necessary or pathognomonic feature ( Fig.…”

Section: Meningiomamentioning

confidence: 99%

“…Depending on their size and location, these lesions may be surprisingly indolent, but certain features such as progressive optic nerve compromise can require emergency intervention. 14 …”

Section: Meningiomamentioning

confidence: 99%

Imaging of skull base tumours

Thust

Yousry

2016

Reports of Practical Oncology & Radiotherapy

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Skull base imagingHead and neck Skull base tumours Oncology a b s t r a c tThe skull base is a highly complex and difficult to access anatomical region, which constitutes a relatively common site for neoplasms. Imaging plays a central role in establishing the differential diagnosis, to determine the anatomic tumour spread and for operative planning. All skull base imaging should be performed using thin-section multiplanar imaging, whereby CT and MRI can be considered complimentary. An interdisciplinary team approach is central to improve the outcome of these challenging tumours.

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Anatomic location is a risk factor for atypical and malignant meningiomas

Kane

Sughrue

Rutkowski

et al. 2010

Cancer

185

101

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Background Grade II and III meningiomas have higher rates of tumor recurrence than grade I meningiomas after surgery and/or external irradiation. As the utility of non-invasive treatments for brain tumors increases, it is becoming increasingly important to assess the likelihood that a tumor is not benign before treatment initiation. Hence, we have reviewed a large-series of our patients to determine risk-factors for higher-grade pathology with particular interest paid towards tumor location. Methods We reviewed 378 patients presenting to our institution from 2000 to 2007 with: histologically confirmed meningioma, central pathology grading according to the WHO 2000 guidelines, and tumor location confirmed with preoperative imaging. We performed univariate and multivariate logistic regression on potential risk-factors for high-grade pathology. Results Risk-factors for grade II/III pathology included non-skull base location (twofold) and male gender (two-fold). Patients with prior surgery had a three-fold increased incidence of higher-grade meningiomas at presentation to our center. We controlled for this referral bias by performing a multivariate regression, and analysis without patients receiving prior treatment. 97% of operations were performed for tumor size and clinical symptoms, while less than 3% for interval growth or features concerning of higher-grade pathology. Conclusion Non-skull-base meningiomas, male gender, and prior surgery impart increased risk for grade II or III pathology. This increased risk translates to probable poorer prognosis and increased likelihood of recurrence after treatment. Thus, it is prudent to take these specific variables into consideration in conjunction with the complete clinical presentation when advising patients regarding their prognosis.

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The natural history of untreated skull base meningiomas

Cited by 80 publications

References 13 publications

The Natural Course of Incidental Intracranial Meningiomas: Systematic Review and Meta-Analysis.

The Natural Course of Incidental Intracranial Meningiomas: Systematic Review and Meta-Analysis.

Imaging of skull base tumours

Anatomic location is a risk factor for atypical and malignant meningiomas

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