The Natural History of Untreated Lung Cancer

Rigler, Leo G.

doi:10.1111/j.1749-6632.1964.tb40994.x

Cited by 11 publications

(2 citation statements)

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“…A 1964 retrospective study of patients with lung cancer, in whom CRs had been made before the definitive diagnosis, revealed an interval between the first CR signs and the first symptoms of 0.8—1 year [ 2 ]. Another retrospective study inferred the duration of the LT from the intervals between CR examinations of patients who adhered to the screening protocol (6 months), and the patients who did not (19.5 months).…”

Section: Resultsmentioning

confidence: 99%

“…Longitudinal studies have either followed prospectively populations at risk by SC [ 1 ], or reviewed retrospectively CRs that had been performed before the clinical diagnosis of lung cancer [ 2 ]. Estimates based on screening trials have inferred the duration of LT from the ratio between the prevalence of lung cancer at the first (baseline) screening round and the annual incidence of cancer during subsequent follow-up [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Duration of lead time in screening for lung cancer

Benbassat

2021

BMC Pulm Med

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Background Screening for lung cancer has used chest radiography (CR), low dose computed tomography (LDCT) and sputum cytology (SC). Estimates of the lead time (LT), i.e., the time interval from detection of lung cancer by screening to the development of symptoms, have been derived from longitudinal studies of populations at risk, tumor doubling time (DT), the ratio between its prevalence at the first round of screening and its annual incidence during follow-up, and by probability modeling derived from the results of screening trials. Objective To review and update the estimates of LT of lung cancer. Methods A non-systematic search of the literature for estimates of LT and screening trials. Search of the reference sections of the retrieved papers for additional relevant studies. Calculation of LTs derived from these studies. Results LT since detection by CR was 0.8–1.1 years if derived from longitudinal studies; 0.6–2.1 years if derived from prevalence / incidence ratios; 0.2 years if derived from the average tumor DT; and 0.2–1.0 if derived from probability modeling. LT since detection by LDCT was 1.1–3.5 if derived from prevalence / incidence ratios; 3.9 if derived from DT; and 0.9 if derived from probability modeling. LT since detection of squamous cell cancer by SC in persons with normal CR was 1.3–1.5 if derived from prevalence/incidence ratios; and 2.1 years if derived from the DT of squamous cell cancer. Conclusions Most estimates of the LT yield values of 0.2–1.5 years for detection by CR; of 0.9–3.5 years for detection by LDCT; and about 2 years or less for detection of squamous cell cancer by SC in persons with normal CR. The heterogeneity of the screening trials and methods of derivation may account for the variability of LT estimates.

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Section: Resultsmentioning

confidence: 99%