1952
DOI: 10.1126/science.115.2978.88
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The Natural Resistance of the Golden Hamster to Colchicine

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Cited by 58 publications
(16 citation statements)
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“…The failure of colchicine to arrest mitotic activity in implanted hamster embryos is in agreement with the observation of Orsini and Panski (1952) regarding the natural resistance of hamster tissue to the anti-mitotic effect of this agent.…”
Section: Resultssupporting
confidence: 71%
See 1 more Smart Citation
“…The failure of colchicine to arrest mitotic activity in implanted hamster embryos is in agreement with the observation of Orsini and Panski (1952) regarding the natural resistance of hamster tissue to the anti-mitotic effect of this agent.…”
Section: Resultssupporting
confidence: 71%
“…
Orsini and Panski (1952) used colchicine in their investigations on the proliferative growth of hamster tissue. They found that injected doses of colchicine varying from O· 1 up to 2 mg per 100 g body weight did not cause any significant v4riation from the normal number of mitoses, and the presence of anaphase and telophase stages with normal spindles in normal ratio suggested that these doses were ineffective.
…”
mentioning
confidence: 99%
“…Results of these studies presented in [9,19,20]. Therefore, it is likely that the sensitivity/toxicity of humans to puromycin may be much greater in comparison to rodent species which are commonly employed to evaluate drug toxicity.…”
Section: Louis Mo) ['H]puromycin and ['Hlleucine Were Purchasedmentioning
confidence: 99%
“…The Golden Hamster appeared to be an experimental animal excellently suited for this purpose because of its low sensitivity to colchicine (5). The LD50 of colchicine for the Golden Hamster is 470 mg/kg as compared to 0.5 mg kg for the guinea pig (4).…”
mentioning
confidence: 99%